Giuseppe
Emeritus
Epidemiologic Study of Human Influenza Infection in Korea from 1999 to 2007: Origin and Evolution of A/Fujian/411/2002-like strains. (J Clin Microbiol., abstract, edited)
[Source: US National Library of Medicine, (LINK). Edited.]
J Clin Microbiol. 2010 Apr 14. [Epub ahead of print]
Epidemiologic Study of Human Influenza Infection in Korea from 1999 to 2007: Origin and Evolution of A/Fujian/411/2002-like strains.
Kang S, Yang IS, Lee JY, Park Y, Oh HB, Kang C, Kim KH. - Department of Biotechnology & Bioinformatics, College of Science & Technology, Korea University, Chungnam, Korea; Center for Infectious Diseases, Korea Centers for Disease Control and Prevention, Seoul, Korea.
Influenza epidemics arise through the accumulation of viral genetic changes, culminating in a novel antigenic type that is able to escape host immunity. Following an outbreak of the A/Fujian/411/2002-like strains in Asia including China, Japan and Korea in 2002, Australia and New Zealand experienced substantial outbreaks of the same strains in 2003 and subsequently worldwide in the 2003-2004 season. The emergence of A/Fujian/411/2002-like strains coincided with a higher level of influenza-like illness in Korea than what is seen at the peak of a normal season, and there was at least a year's difference between Korea and the U.S.A. Genetic evolution of human influenza A/H3N2 viruses was monitored by sequence analysis of hemagglutinin (HA) genes collected in Asia including 269 (164 new) HA genes isolated in Korea from 1999 to 2007. The Fujian-like influenza strains were disseminated with rapid sequence variation across the antigenic sites of the HA1 domain, which sharply distinguished between the A/Moscow /10/1999-like and A/Fujian/411/2002-like strains. This fast variation, equivalent to approximately 10 amino acid changes within a year, had occurred in Asia, and would be the main cause of the disappearance of the reassortants, although the reassortant and non-reassortant Fujian-like strains simultaneously circulated in Asia.
PMID: 20392920 [PubMed - as supplied by publisher]
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[Source: US National Library of Medicine, (LINK). Edited.]
J Clin Microbiol. 2010 Apr 14. [Epub ahead of print]
Epidemiologic Study of Human Influenza Infection in Korea from 1999 to 2007: Origin and Evolution of A/Fujian/411/2002-like strains.
Kang S, Yang IS, Lee JY, Park Y, Oh HB, Kang C, Kim KH. - Department of Biotechnology & Bioinformatics, College of Science & Technology, Korea University, Chungnam, Korea; Center for Infectious Diseases, Korea Centers for Disease Control and Prevention, Seoul, Korea.
Influenza epidemics arise through the accumulation of viral genetic changes, culminating in a novel antigenic type that is able to escape host immunity. Following an outbreak of the A/Fujian/411/2002-like strains in Asia including China, Japan and Korea in 2002, Australia and New Zealand experienced substantial outbreaks of the same strains in 2003 and subsequently worldwide in the 2003-2004 season. The emergence of A/Fujian/411/2002-like strains coincided with a higher level of influenza-like illness in Korea than what is seen at the peak of a normal season, and there was at least a year's difference between Korea and the U.S.A. Genetic evolution of human influenza A/H3N2 viruses was monitored by sequence analysis of hemagglutinin (HA) genes collected in Asia including 269 (164 new) HA genes isolated in Korea from 1999 to 2007. The Fujian-like influenza strains were disseminated with rapid sequence variation across the antigenic sites of the HA1 domain, which sharply distinguished between the A/Moscow /10/1999-like and A/Fujian/411/2002-like strains. This fast variation, equivalent to approximately 10 amino acid changes within a year, had occurred in Asia, and would be the main cause of the disappearance of the reassortants, although the reassortant and non-reassortant Fujian-like strains simultaneously circulated in Asia.
PMID: 20392920 [PubMed - as supplied by publisher]
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------