Giuseppe
Emeritus
[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
J Clin Microbiol. 2013 Oct 2. [Epub ahead of print]
Emergence of an oseltamivir-resistant influenza A/H3N2 virus in an elderly receiving a suboptimal dose of antiviral prophylaxis.
Roussy JF, Abed Y, Bouhy X, Boivin G.
Source: Research Center in Infectious Diseases of the CHU of Qu?bec and Laval University, Qu?bec City, Qu?bec, Canada.
Abstract
We report on the emergence of an influenza A/H3N2-E119V neuraminidase variant from an elderly with renal dysfunction who received a suboptimal dose of oseltamivir prophylaxis. In neuraminidase inhibition assays, the E119V variant showed a 413-fold increase in oseltamivir IC50 value and grew at comparable titers than the wild-type in vitro.
PMID: 24088848 [PubMed - as supplied by publisher]
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J Clin Microbiol. 2013 Oct 2. [Epub ahead of print]
Emergence of an oseltamivir-resistant influenza A/H3N2 virus in an elderly receiving a suboptimal dose of antiviral prophylaxis.
Roussy JF, Abed Y, Bouhy X, Boivin G.
Source: Research Center in Infectious Diseases of the CHU of Qu?bec and Laval University, Qu?bec City, Qu?bec, Canada.
Abstract
We report on the emergence of an influenza A/H3N2-E119V neuraminidase variant from an elderly with renal dysfunction who received a suboptimal dose of oseltamivir prophylaxis. In neuraminidase inhibition assays, the E119V variant showed a 413-fold increase in oseltamivir IC50 value and grew at comparable titers than the wild-type in vitro.
PMID: 24088848 [PubMed - as supplied by publisher]
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