tetano
Editor, Senior Moderator
J Clin Med
. 2021 Jul 6;10(14):3015.
doi: 10.3390/jcm10143015.
The Link between SARS-CoV-2 Infection, Inflammation and Hypercoagulability-Impact of Hemorheologic Alterations on Cardiovascular Mortality
Johanna Sandor-Keri[SUP] 1 [/SUP], Istvan Benedek[SUP] 2 [/SUP], Stefania Polexa[SUP] 1 [/SUP], Imre Benedek[SUP] 1 [/SUP]
Affiliations
Abstract
The link between severe forms of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and cardiovascular diseases has been well documented by various studies that indicated a higher risk of cardiovascular complications in COVID-19 patients, in parallel with a higher risk of mortality in COVID-19 patients with underlying cardiovascular diseases. It seems that inflammation, which is a major pathophysiological substrate for both acute myocardial infarction and severe forms of COVID-19, may play a pivotal role in the interrelation between these two critical conditions, and hypercoagulability associated with SARS-CoV-2 infection could be responsible for acute cardiovascular complications. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) proved to be independent predictors for prognosis in acute coronary syndromes and systemic inflammatory diseases; therefore, they may be used as independent prognostic markers of disease severity in COVID-19 infection. The aim of this review is to present the most recent advances in understanding the complex link between SARS-CoV-2 infection, inflammation and alteration of blood coagulability and hemorheology, leading to major cardiovascular events.
Keywords: NLR; PLR; SARS-CoV-2; hemorheology; hypercoagulability; inflammation; myocardial infarction.
. 2021 Jul 6;10(14):3015.
doi: 10.3390/jcm10143015.
The Link between SARS-CoV-2 Infection, Inflammation and Hypercoagulability-Impact of Hemorheologic Alterations on Cardiovascular Mortality
Johanna Sandor-Keri[SUP] 1 [/SUP], Istvan Benedek[SUP] 2 [/SUP], Stefania Polexa[SUP] 1 [/SUP], Imre Benedek[SUP] 1 [/SUP]
Affiliations
- PMID: 34300181
- DOI: 10.3390/jcm10143015
Abstract
The link between severe forms of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and cardiovascular diseases has been well documented by various studies that indicated a higher risk of cardiovascular complications in COVID-19 patients, in parallel with a higher risk of mortality in COVID-19 patients with underlying cardiovascular diseases. It seems that inflammation, which is a major pathophysiological substrate for both acute myocardial infarction and severe forms of COVID-19, may play a pivotal role in the interrelation between these two critical conditions, and hypercoagulability associated with SARS-CoV-2 infection could be responsible for acute cardiovascular complications. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) proved to be independent predictors for prognosis in acute coronary syndromes and systemic inflammatory diseases; therefore, they may be used as independent prognostic markers of disease severity in COVID-19 infection. The aim of this review is to present the most recent advances in understanding the complex link between SARS-CoV-2 infection, inflammation and alteration of blood coagulability and hemorheology, leading to major cardiovascular events.
Keywords: NLR; PLR; SARS-CoV-2; hemorheology; hypercoagulability; inflammation; myocardial infarction.