tetano
Editor, Senior Moderator
J Clin Med
. 2021 Oct 24;10(21):4914.
doi: 10.3390/jcm10214914.
Soluble Urokinase Receptor as a Promising Marker for Early Prediction of Outcome in COVID-19 Hospitalized Patients
Filomena Napolitano[SUP] 1 [/SUP], Gaetano Di Spigna[SUP] 1 [/SUP], Maria Vargas[SUP] 2 [/SUP], Carmine Iacovazzo[SUP] 2 [/SUP], Biagio Pinchera[SUP] 3 [/SUP], Daniela Spalletti Cernia[SUP] 1 [/SUP], Margherita Ricciardone[SUP] 1 [/SUP], Bianca Covelli[SUP] 1 [/SUP], Giuseppe Servillo[SUP] 2 [/SUP], Ivan Gentile[SUP] 3 [/SUP], Loredana Postiglione[SUP] 1 [/SUP], Nunzia Montuori[SUP] 1 [/SUP]
Affiliations
Abstract
The Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has rapidly spread to become a global pandemic, putting a strain on health care systems. SARS-CoV-2 infection may be associated with mild symptoms or, in severe cases, lead patients to the intensive care unit (ICU) or death. The critically ill patients suffer from acute respiratory distress syndrome (ARDS), sepsis, thrombotic complications and multiple organ failure. For optimization of hospital resources, several molecular markers and algorithms have been evaluated in order to stratify COVID-19 patients, based on the risk of developing a mild, moderate, or severe disease. Here, we propose the soluble urokinase receptor (suPAR) as a serum biomarker of clinical severity and outcome in patients who are hospitalized with COVID-19. In patients with mild disease course, suPAR levels were increased as compared to healthy controls, but they were dramatically higher in severely ill patients. Since early identification of disease progression may facilitate the individual management of COVID-19 symptomatic patients and the time of admission to the ICU, we suggest paying more clinical attention on patients with high suPAR levels.
Keywords: ARDS; COVID-19; biomarkers; complement system; risk stratification in the emergency room; sepsis; suPAR.
. 2021 Oct 24;10(21):4914.
doi: 10.3390/jcm10214914.
Soluble Urokinase Receptor as a Promising Marker for Early Prediction of Outcome in COVID-19 Hospitalized Patients
Filomena Napolitano[SUP] 1 [/SUP], Gaetano Di Spigna[SUP] 1 [/SUP], Maria Vargas[SUP] 2 [/SUP], Carmine Iacovazzo[SUP] 2 [/SUP], Biagio Pinchera[SUP] 3 [/SUP], Daniela Spalletti Cernia[SUP] 1 [/SUP], Margherita Ricciardone[SUP] 1 [/SUP], Bianca Covelli[SUP] 1 [/SUP], Giuseppe Servillo[SUP] 2 [/SUP], Ivan Gentile[SUP] 3 [/SUP], Loredana Postiglione[SUP] 1 [/SUP], Nunzia Montuori[SUP] 1 [/SUP]
Affiliations
- PMID: 34768433
- DOI: 10.3390/jcm10214914
Abstract
The Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has rapidly spread to become a global pandemic, putting a strain on health care systems. SARS-CoV-2 infection may be associated with mild symptoms or, in severe cases, lead patients to the intensive care unit (ICU) or death. The critically ill patients suffer from acute respiratory distress syndrome (ARDS), sepsis, thrombotic complications and multiple organ failure. For optimization of hospital resources, several molecular markers and algorithms have been evaluated in order to stratify COVID-19 patients, based on the risk of developing a mild, moderate, or severe disease. Here, we propose the soluble urokinase receptor (suPAR) as a serum biomarker of clinical severity and outcome in patients who are hospitalized with COVID-19. In patients with mild disease course, suPAR levels were increased as compared to healthy controls, but they were dramatically higher in severely ill patients. Since early identification of disease progression may facilitate the individual management of COVID-19 symptomatic patients and the time of admission to the ICU, we suggest paying more clinical attention on patients with high suPAR levels.
Keywords: ARDS; COVID-19; biomarkers; complement system; risk stratification in the emergency room; sepsis; suPAR.