tetano
Editor, Senior Moderator
J Clin Med Res
. 2021 Aug;13(8):420-424.
doi: 10.14740/jocmr4578. Epub 2021 Aug 30.
Perinatal Transmission and Clinical Outcomes of Neonates Born to SARS-CoV-2-Positive Mothers
Manar Al-Lawama[SUP] 1 [/SUP], Eman Badran[SUP] 1 [/SUP], Noor Ghanim[SUP] 1 [/SUP], Ayah Irsheid[SUP] 1 [/SUP], Hiba Qtaishat[SUP] 1 [/SUP], Iyad Al-Ammouri[SUP] 1 [/SUP], Enas Al-Zyadneh[SUP] 1 [/SUP], Montaha Al-Iede[SUP] 1 [/SUP], Amira H Daher[SUP] 1 [/SUP], Fares G Bakri[SUP] 2 3 [/SUP], Ghada Massad[SUP] 4 [/SUP]
Affiliations
Abstract
Background: The aim of the study was to investigate the clinical outcomes and rate of virus detection in neonates born to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive mothers.
Methods: This prospective study included neonates born to SARS-CoV-2-positive mothers, documenting their viral polymerase chain reaction results and clinical outcomes.
Results: Of the 130 neonates born to 122 SARS-CoV-2-positive mothers, 12% tested positive. Most (62%) neonates were delivered via cesarean section at an average gestational age of 36 weeks, with a birth weight of 2,900 g. Only 38% neonates required admission. SARS-CoV-2-positive infants were born at a significantly lower gestational age; had a significantly lower birth weight; and had significantly higher admission rates, surfactant therapy, and bradycardia than SARS-CoV-2-negative infants. There was no significant difference in mortality rates.
Conclusion: This study documents perinatal transmission of SARS-CoV-2. It reports for the first time the occurrence of neonatal bradycardia as a complication of maternal SARS-CoV-2 infection. Despite that, neonates born to SARS-CoV-2-positive mothers had relatively good short-term outcomes.
Keywords: COVID-19; Clinical outcome; Neonate; Perinatal transmission.
. 2021 Aug;13(8):420-424.
doi: 10.14740/jocmr4578. Epub 2021 Aug 30.
Perinatal Transmission and Clinical Outcomes of Neonates Born to SARS-CoV-2-Positive Mothers
Manar Al-Lawama[SUP] 1 [/SUP], Eman Badran[SUP] 1 [/SUP], Noor Ghanim[SUP] 1 [/SUP], Ayah Irsheid[SUP] 1 [/SUP], Hiba Qtaishat[SUP] 1 [/SUP], Iyad Al-Ammouri[SUP] 1 [/SUP], Enas Al-Zyadneh[SUP] 1 [/SUP], Montaha Al-Iede[SUP] 1 [/SUP], Amira H Daher[SUP] 1 [/SUP], Fares G Bakri[SUP] 2 3 [/SUP], Ghada Massad[SUP] 4 [/SUP]
Affiliations
- PMID: 34527097
- PMCID: PMC8425792
- DOI: 10.14740/jocmr4578
Abstract
Background: The aim of the study was to investigate the clinical outcomes and rate of virus detection in neonates born to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive mothers.
Methods: This prospective study included neonates born to SARS-CoV-2-positive mothers, documenting their viral polymerase chain reaction results and clinical outcomes.
Results: Of the 130 neonates born to 122 SARS-CoV-2-positive mothers, 12% tested positive. Most (62%) neonates were delivered via cesarean section at an average gestational age of 36 weeks, with a birth weight of 2,900 g. Only 38% neonates required admission. SARS-CoV-2-positive infants were born at a significantly lower gestational age; had a significantly lower birth weight; and had significantly higher admission rates, surfactant therapy, and bradycardia than SARS-CoV-2-negative infants. There was no significant difference in mortality rates.
Conclusion: This study documents perinatal transmission of SARS-CoV-2. It reports for the first time the occurrence of neonatal bradycardia as a complication of maternal SARS-CoV-2 infection. Despite that, neonates born to SARS-CoV-2-positive mothers had relatively good short-term outcomes.
Keywords: COVID-19; Clinical outcome; Neonate; Perinatal transmission.