tetano
Editor, Senior Moderator
J Clin Med
. 2022 Oct 27;11(21):6348.
doi: 10.3390/jcm11216348.
Reduced Risk of Progression from Non-Severe to Severe COVID-19 in Hospitalized Dialysis Patients by Full COVID-19 Vaccination
Mitsuru Ichii[SUP] 1 [/SUP], Masafumi Kurajoh[SUP] 2 [/SUP], Yujiro Okute[SUP] 1 [/SUP], Yasutaka Ihara[SUP] 3 [/SUP], Takumi Imai[SUP] 3 [/SUP], Tomoaki Morioka[SUP] 2 [/SUP], Katsuhito Mori[SUP] 4 [/SUP], Tetsuo Shoji[SUP] 5 [/SUP], Yoshihiro Tsujimoto[SUP] 1 [/SUP], Takanobu Ubai[SUP] 6 [/SUP], Masanori Emoto[SUP] 2 4 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) vaccination reduces the risk of progression to severe COVID-19 in the general population. To examine that preventive effect in dialysis patients, the association of vaccination status with severe COVID-19 progression was investigated in this retrospective observational study conducted from December 2020 to May 2022 of 100 such patients hospitalized for non-severe COVID-19 at Inoue Hospital (Suita, Japan). Fifty-seven were fully vaccinated, defined as receiving a COVID-19 vaccine second dose at least 14 days prior to the onset of COVID-19, while 43 were not. Among all patients, 13 (13.0%) progressed to severe COVID-19 with a median (interquartile range) time of 6 (2.5-9.5) days, while 87 (87.0%) were discharged after 11 (8-16) days. Kaplan-Meier analysis showed that fully vaccinated patients had a significantly lower rate of progression to severe COVID-19 (p = 0.001, log-rank test). Cox proportional hazard analysis also indicated that full COVID-19 vaccination was significantly associated with reduced instances of progression to severe COVID-19 (hazard ratio 0.104, 95% confidence interval 0.022 to 0.483; p = 0.004) after balancing patient background characteristics using an inverse probability of treatment weight method. These results suggest that full vaccination status contributes to reducing the risk of progression from non-severe to severe COVID-19 in dialysis patients.
Keywords: COVID-19; dialysis patients; full vaccination; severe progression.
. 2022 Oct 27;11(21):6348.
doi: 10.3390/jcm11216348.
Reduced Risk of Progression from Non-Severe to Severe COVID-19 in Hospitalized Dialysis Patients by Full COVID-19 Vaccination
Mitsuru Ichii[SUP] 1 [/SUP], Masafumi Kurajoh[SUP] 2 [/SUP], Yujiro Okute[SUP] 1 [/SUP], Yasutaka Ihara[SUP] 3 [/SUP], Takumi Imai[SUP] 3 [/SUP], Tomoaki Morioka[SUP] 2 [/SUP], Katsuhito Mori[SUP] 4 [/SUP], Tetsuo Shoji[SUP] 5 [/SUP], Yoshihiro Tsujimoto[SUP] 1 [/SUP], Takanobu Ubai[SUP] 6 [/SUP], Masanori Emoto[SUP] 2 4 [/SUP]
Affiliations
- PMID: 36362579
- DOI: 10.3390/jcm11216348
Abstract
Coronavirus disease 2019 (COVID-19) vaccination reduces the risk of progression to severe COVID-19 in the general population. To examine that preventive effect in dialysis patients, the association of vaccination status with severe COVID-19 progression was investigated in this retrospective observational study conducted from December 2020 to May 2022 of 100 such patients hospitalized for non-severe COVID-19 at Inoue Hospital (Suita, Japan). Fifty-seven were fully vaccinated, defined as receiving a COVID-19 vaccine second dose at least 14 days prior to the onset of COVID-19, while 43 were not. Among all patients, 13 (13.0%) progressed to severe COVID-19 with a median (interquartile range) time of 6 (2.5-9.5) days, while 87 (87.0%) were discharged after 11 (8-16) days. Kaplan-Meier analysis showed that fully vaccinated patients had a significantly lower rate of progression to severe COVID-19 (p = 0.001, log-rank test). Cox proportional hazard analysis also indicated that full COVID-19 vaccination was significantly associated with reduced instances of progression to severe COVID-19 (hazard ratio 0.104, 95% confidence interval 0.022 to 0.483; p = 0.004) after balancing patient background characteristics using an inverse probability of treatment weight method. These results suggest that full vaccination status contributes to reducing the risk of progression from non-severe to severe COVID-19 in dialysis patients.
Keywords: COVID-19; dialysis patients; full vaccination; severe progression.