tetano
Editor, Senior Moderator
J Clin Med
. 2022 Jul 29;11(15):4420.
doi: 10.3390/jcm11154420.
Protective Effects of BNT162b2 Vaccination on Aerobic Capacity Following Mild to Moderate SARS-CoV-2 Infection: A Cross-Sectional Study Israel
Yair Blumberg[SUP] 1 2 [/SUP], Michael Edelstein[SUP] 1 2 [/SUP], Kamal Abu Jabal[SUP] 1 2 [/SUP], Ron Golan[SUP] 1 [/SUP], Neta Tuvia[SUP] 1 [/SUP], Yuval Perets[SUP] 2 [/SUP], Musa Saad[SUP] 1 [/SUP], Tatyana Levinas[SUP] 1 2 [/SUP], Dabbah Saleem[SUP] 1 [/SUP], Zeev Israeli[SUP] 1 2 [/SUP], Abu Raya Alaa[SUP] 1 [/SUP], Gabby Elbaz Greener[SUP] 2 3 [/SUP], Anat Amital[SUP] 1 [/SUP], Majdi Halabi[SUP] 1 2 [/SUP]
Affiliations
Abstract
Patients previously infected with acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may experience post-acute adverse health outcomes, known as long COVID. The most reported symptoms are fatigue, headache and attention/concentration issues, dyspnea and myalgia. In addition, reduced aerobic capacity has been demonstrated in both mild and moderate COVID-19 patients. It is unknown whether COVID-19 vaccination mitigates against reduced aerobic capacity. Our aim was to compare the aerobic capacity of vaccinated and unvaccinated individuals previously infected with SARS-CoV-2.
Methods: Individuals aged 18 to 65 years with laboratory-confirmed mild to moderate COVID-19 disease were invited to Ziv Medical Centre, Israel, three months after SARS-CoV-2 infection. We compared individuals unvaccinated at the time of infection to those vaccinated in terms of aerobic capacity, measured using symptom-limited cardiopulmonary exercise test (CPET).
Results: We recruited 28 unvaccinated and 22 vaccinated patients. There were no differences in baseline demographic and pulmonary function testing (PFT) parameters. Compared with unvaccinated individuals, those vaccinated had higher V'O[SUB]2[/SUB]/kg at peak exercise and at the anaerobic threshold. The V'O[SUB]2[/SUB]/kg peak in the unvaccinated group was 83% of predicted vs. 100% in the vaccinated (p < 0.002). At the anaerobic threshold (AT), vaccinated individuals had a higher V'O[SUB]2[/SUB]/kg than those unvaccinated.
Conclusions: Vaccinated individuals had significantly better exercise performance. Compared with vaccinated individuals, a higher proportion of those unvaccinated performed substantially worse than expected on CPET. These results suggest that vaccination at the time of infection is associated with better aerobic capacity following SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; aerobic capacity; vaccination.
. 2022 Jul 29;11(15):4420.
doi: 10.3390/jcm11154420.
Protective Effects of BNT162b2 Vaccination on Aerobic Capacity Following Mild to Moderate SARS-CoV-2 Infection: A Cross-Sectional Study Israel
Yair Blumberg[SUP] 1 2 [/SUP], Michael Edelstein[SUP] 1 2 [/SUP], Kamal Abu Jabal[SUP] 1 2 [/SUP], Ron Golan[SUP] 1 [/SUP], Neta Tuvia[SUP] 1 [/SUP], Yuval Perets[SUP] 2 [/SUP], Musa Saad[SUP] 1 [/SUP], Tatyana Levinas[SUP] 1 2 [/SUP], Dabbah Saleem[SUP] 1 [/SUP], Zeev Israeli[SUP] 1 2 [/SUP], Abu Raya Alaa[SUP] 1 [/SUP], Gabby Elbaz Greener[SUP] 2 3 [/SUP], Anat Amital[SUP] 1 [/SUP], Majdi Halabi[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35956037
- DOI: 10.3390/jcm11154420
Abstract
Patients previously infected with acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may experience post-acute adverse health outcomes, known as long COVID. The most reported symptoms are fatigue, headache and attention/concentration issues, dyspnea and myalgia. In addition, reduced aerobic capacity has been demonstrated in both mild and moderate COVID-19 patients. It is unknown whether COVID-19 vaccination mitigates against reduced aerobic capacity. Our aim was to compare the aerobic capacity of vaccinated and unvaccinated individuals previously infected with SARS-CoV-2.
Methods: Individuals aged 18 to 65 years with laboratory-confirmed mild to moderate COVID-19 disease were invited to Ziv Medical Centre, Israel, three months after SARS-CoV-2 infection. We compared individuals unvaccinated at the time of infection to those vaccinated in terms of aerobic capacity, measured using symptom-limited cardiopulmonary exercise test (CPET).
Results: We recruited 28 unvaccinated and 22 vaccinated patients. There were no differences in baseline demographic and pulmonary function testing (PFT) parameters. Compared with unvaccinated individuals, those vaccinated had higher V'O[SUB]2[/SUB]/kg at peak exercise and at the anaerobic threshold. The V'O[SUB]2[/SUB]/kg peak in the unvaccinated group was 83% of predicted vs. 100% in the vaccinated (p < 0.002). At the anaerobic threshold (AT), vaccinated individuals had a higher V'O[SUB]2[/SUB]/kg than those unvaccinated.
Conclusions: Vaccinated individuals had significantly better exercise performance. Compared with vaccinated individuals, a higher proportion of those unvaccinated performed substantially worse than expected on CPET. These results suggest that vaccination at the time of infection is associated with better aerobic capacity following SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; aerobic capacity; vaccination.