tetano
Editor, Senior Moderator
J Clin Med
. 2021 Jan 17;10(2):E323.
doi: 10.3390/jcm10020323.
Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection
Laia C Belarte-Tornero[SUP] 1 2 [/SUP], Sandra Valdivielso-Mor?[SUP] 1 [/SUP], Miren Vicente Elcano[SUP] 3 [/SUP], Eduard Sol?-Gonz?lez[SUP] 1 [/SUP], Sonia Ru?z-Bustillo[SUP] 1 4 [/SUP], Alicia Calvo-Fern?ndez[SUP] 1 2 [/SUP], Isaac Subinara[SUP] 5 [/SUP], Paula Cabero[SUP] 2 3 [/SUP], Cristina Soler[SUP] 2 [/SUP], H?ctor Cubero-Gallego[SUP] 2 3 [/SUP], Beatriz Vaquerizo[SUP] 2 3 4 [/SUP], N?ria Farr?[SUP] 1 2 4 [/SUP]
Affiliations
Abstract
Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting.
Methods: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored.
Results: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHF patients (51.2% vs. 29.1%, p = 0.014). CHF was independently associated with 30-day mortality (hazard ratio (HR) 2.3, confidence interval (CI) 95%: 1.26-2.4). Patients with CHF and high-sensitivity troponin T < 14 ng/L showed excellent prognosis. An NT-proBNP level > 2598 pg/mL on admission was associated with higher 30-day mortality in patients with CHF.
Conclusions: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51.2%. CHF was independently associated with all-cause mortality (HR 2.3, CI 95% 1.26-4.2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding.
Keywords: COVID-19; NT-proBNP; SARS-CoV-2; biomarkers; coronavirus; heart failure; prognosis; troponin.
. 2021 Jan 17;10(2):E323.
doi: 10.3390/jcm10020323.
Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection
Laia C Belarte-Tornero[SUP] 1 2 [/SUP], Sandra Valdivielso-Mor?[SUP] 1 [/SUP], Miren Vicente Elcano[SUP] 3 [/SUP], Eduard Sol?-Gonz?lez[SUP] 1 [/SUP], Sonia Ru?z-Bustillo[SUP] 1 4 [/SUP], Alicia Calvo-Fern?ndez[SUP] 1 2 [/SUP], Isaac Subinara[SUP] 5 [/SUP], Paula Cabero[SUP] 2 3 [/SUP], Cristina Soler[SUP] 2 [/SUP], H?ctor Cubero-Gallego[SUP] 2 3 [/SUP], Beatriz Vaquerizo[SUP] 2 3 4 [/SUP], N?ria Farr?[SUP] 1 2 4 [/SUP]
Affiliations
- PMID: 33477268
- DOI: 10.3390/jcm10020323
Abstract
Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting.
Methods: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored.
Results: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHF patients (51.2% vs. 29.1%, p = 0.014). CHF was independently associated with 30-day mortality (hazard ratio (HR) 2.3, confidence interval (CI) 95%: 1.26-2.4). Patients with CHF and high-sensitivity troponin T < 14 ng/L showed excellent prognosis. An NT-proBNP level > 2598 pg/mL on admission was associated with higher 30-day mortality in patients with CHF.
Conclusions: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51.2%. CHF was independently associated with all-cause mortality (HR 2.3, CI 95% 1.26-4.2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding.
Keywords: COVID-19; NT-proBNP; SARS-CoV-2; biomarkers; coronavirus; heart failure; prognosis; troponin.