tetano
Editor, Senior Moderator
J Clin Med
. 2020 Aug 27;9(9):E2780.
doi: 10.3390/jcm9092780.
Prevalence of Antibodies to SARS-CoV-2 in Italian Adults and Associated Risk Factors
Antonio Vena[SUP] 1 [/SUP], Marco Berruti[SUP] 1 2 [/SUP], Andrea Adessi[SUP] 3 [/SUP], Pietro Blumetti[SUP] 4 [/SUP], Michele Brignole[SUP] 5 6 [/SUP], Renato Colognato[SUP] 4 [/SUP], Germano Gaggioli[SUP] 7 [/SUP], Daniele Roberto Giacobbe[SUP] 1 [/SUP], Luisa Bracci-Laudiero[SUP] 8 9 [/SUP], Laura Magnasco[SUP] 1 [/SUP], Alessio Signori[SUP] 10 [/SUP], Lucia Taramasso[SUP] 1 [/SUP], Marco Varelli[SUP] 11 [/SUP], Nicoletta Vendola[SUP] 12 [/SUP], Lorenzo Ball[SUP] 13 14 [/SUP], Chiara Robba[SUP] 14 [/SUP], Denise Battaglini[SUP] 14 [/SUP], Iole Brunetti[SUP] 14 [/SUP], Paolo Pelosi[SUP] 13 14 [/SUP], Matteo Bassetti[SUP] 1 2 [/SUP]
Affiliations
Abstract
We aimed to assess the prevalence of and factors associated with anti- severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) positivity in a large population of adult volunteers from five administrative departments of the Liguria and Lombardia regions. A total of 3609 individuals were included in this analysis. Participants were tested for anti-SARS-CoV-2 antibodies [Immunoglobulin G (IgG) and M (IgM) class antibodies] at three private laboratories (Istituto Diganostico Varelli, Medical Center, and Casa della Salute di Genova). Demographic data, occupational or private exposure to SARS-CoV-2-infected patients, and prior medical history consistent with SARS-CoV-2 infection were collected according to a preplanned analysis. The overall seroprevalence of anti-SARS-CoV-2 antibodies (IgG and/or IgM) was 11.0% [398/3609; confidence interval (CI) 10.0%-12.1%]. Seroprevalence was higher in female inmates than in male inmates (12.5% vs. 9.2%, respectively, p = 0.002), with the highest rate observed among adults aged >55 years (13.2%). A generalized estimating equations model showed that the main risk factors associated with SARS-CoV-2 seroprevalence were the following: an occupational exposure to the virus [Odd ratio (OR) = 2.36; 95% CI 1.59-3.50, p = 0.001], being a long-term care facility resident (OR = 4.53; 95% CI 3.19-6.45, p = 0.001), and reporting previous symptoms of influenza-like illness (OR = 4.86; 95% CI 3.75-6.30, p = 0.001) or loss of sense of smell or taste (OR = 41.00; 95% CI 18.94-88.71, p = 0.001). In conclusion, we found a high prevalence (11.0%) of SARS-CoV-2 infection that is significantly associated with residing in long-term care facilities or occupational exposure to the virus. These findings warrant further investigation into SARS-CoV-2 antibody prevalence among the Italian population.
Keywords: COVID-19; SARS-CoV-2; antibodies; serological test.
. 2020 Aug 27;9(9):E2780.
doi: 10.3390/jcm9092780.
Prevalence of Antibodies to SARS-CoV-2 in Italian Adults and Associated Risk Factors
Antonio Vena[SUP] 1 [/SUP], Marco Berruti[SUP] 1 2 [/SUP], Andrea Adessi[SUP] 3 [/SUP], Pietro Blumetti[SUP] 4 [/SUP], Michele Brignole[SUP] 5 6 [/SUP], Renato Colognato[SUP] 4 [/SUP], Germano Gaggioli[SUP] 7 [/SUP], Daniele Roberto Giacobbe[SUP] 1 [/SUP], Luisa Bracci-Laudiero[SUP] 8 9 [/SUP], Laura Magnasco[SUP] 1 [/SUP], Alessio Signori[SUP] 10 [/SUP], Lucia Taramasso[SUP] 1 [/SUP], Marco Varelli[SUP] 11 [/SUP], Nicoletta Vendola[SUP] 12 [/SUP], Lorenzo Ball[SUP] 13 14 [/SUP], Chiara Robba[SUP] 14 [/SUP], Denise Battaglini[SUP] 14 [/SUP], Iole Brunetti[SUP] 14 [/SUP], Paolo Pelosi[SUP] 13 14 [/SUP], Matteo Bassetti[SUP] 1 2 [/SUP]
Affiliations
- PMID: 32867328
- DOI: 10.3390/jcm9092780
Abstract
We aimed to assess the prevalence of and factors associated with anti- severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) positivity in a large population of adult volunteers from five administrative departments of the Liguria and Lombardia regions. A total of 3609 individuals were included in this analysis. Participants were tested for anti-SARS-CoV-2 antibodies [Immunoglobulin G (IgG) and M (IgM) class antibodies] at three private laboratories (Istituto Diganostico Varelli, Medical Center, and Casa della Salute di Genova). Demographic data, occupational or private exposure to SARS-CoV-2-infected patients, and prior medical history consistent with SARS-CoV-2 infection were collected according to a preplanned analysis. The overall seroprevalence of anti-SARS-CoV-2 antibodies (IgG and/or IgM) was 11.0% [398/3609; confidence interval (CI) 10.0%-12.1%]. Seroprevalence was higher in female inmates than in male inmates (12.5% vs. 9.2%, respectively, p = 0.002), with the highest rate observed among adults aged >55 years (13.2%). A generalized estimating equations model showed that the main risk factors associated with SARS-CoV-2 seroprevalence were the following: an occupational exposure to the virus [Odd ratio (OR) = 2.36; 95% CI 1.59-3.50, p = 0.001], being a long-term care facility resident (OR = 4.53; 95% CI 3.19-6.45, p = 0.001), and reporting previous symptoms of influenza-like illness (OR = 4.86; 95% CI 3.75-6.30, p = 0.001) or loss of sense of smell or taste (OR = 41.00; 95% CI 18.94-88.71, p = 0.001). In conclusion, we found a high prevalence (11.0%) of SARS-CoV-2 infection that is significantly associated with residing in long-term care facilities or occupational exposure to the virus. These findings warrant further investigation into SARS-CoV-2 antibody prevalence among the Italian population.
Keywords: COVID-19; SARS-CoV-2; antibodies; serological test.