tetano
Editor, Senior Moderator
J Clin Med
. 2022 Nov 18;11(22):6827.
doi: 10.3390/jcm11226827.
Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature
Claudia Brogna[SUP] 1 [/SUP], Barbara Brogna[SUP] 2 [/SUP], Margherita De Biase[SUP] 3 [/SUP], Francesca Sini[SUP] 1 [/SUP], Federica Mirra[SUP] 3 [/SUP], Marianna Moro[SUP] 3 [/SUP], Domenico M Romeo[SUP] 1 3 [/SUP]
Affiliations
Abstract
Perinatal stroke is related to possible differences in predisposing factors and outcomes between acutely and retrospectively diagnosed cases. In most cases, there are different risk factors and infections that could play an important role. Thus far, different clinical manifestations have been reported in children presenting with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from asymptomatic status to severe disease sustained by an immune-mediated inflammatory response. SARS-CoV-2 has been associated with severe neurological diseases including seizures and encephalitis in both adults and children. However, there are still few reports regarding the possible relation between SARS-CoV-2 infection of mothers during pregnancy and the neurologic outcome of the newborns. We described the case of a newborn diagnosed with a perinatal stroke, born at 35 weeks of gestation from a mother presenting with SARS- CoV-2 infection during the last months of pregnancy. We also added a brief review of the literature with similar cases. Close monitoring and early intervention in young children born to infected mothers would be highly recommended for the potential neurodevelopmental risk.
Keywords: SARS-CoV-2; ischemic lesion; neonate; pregnancy.
. 2022 Nov 18;11(22):6827.
doi: 10.3390/jcm11226827.
Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature
Claudia Brogna[SUP] 1 [/SUP], Barbara Brogna[SUP] 2 [/SUP], Margherita De Biase[SUP] 3 [/SUP], Francesca Sini[SUP] 1 [/SUP], Federica Mirra[SUP] 3 [/SUP], Marianna Moro[SUP] 3 [/SUP], Domenico M Romeo[SUP] 1 3 [/SUP]
Affiliations
- PMID: 36431302
- DOI: 10.3390/jcm11226827
Abstract
Perinatal stroke is related to possible differences in predisposing factors and outcomes between acutely and retrospectively diagnosed cases. In most cases, there are different risk factors and infections that could play an important role. Thus far, different clinical manifestations have been reported in children presenting with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from asymptomatic status to severe disease sustained by an immune-mediated inflammatory response. SARS-CoV-2 has been associated with severe neurological diseases including seizures and encephalitis in both adults and children. However, there are still few reports regarding the possible relation between SARS-CoV-2 infection of mothers during pregnancy and the neurologic outcome of the newborns. We described the case of a newborn diagnosed with a perinatal stroke, born at 35 weeks of gestation from a mother presenting with SARS- CoV-2 infection during the last months of pregnancy. We also added a brief review of the literature with similar cases. Close monitoring and early intervention in young children born to infected mothers would be highly recommended for the potential neurodevelopmental risk.
Keywords: SARS-CoV-2; ischemic lesion; neonate; pregnancy.