tetano
Editor, Senior Moderator
J Clin Med
. 2021 Feb 9;10(4):671.
doi: 10.3390/jcm10040671.
No Evidence for Classic Thrombotic Microangiopathy in COVID-19
Tanja Falter[SUP] 1 [/SUP], Heidi Rossmann[SUP] 1 [/SUP], Philipp Menge[SUP] 2 [/SUP], Jan Goetje[SUP] 2 [/SUP], Steffen Groenwoldt[SUP] 2 [/SUP], Arndt Weinmann[SUP] 2 3 [/SUP], Visvakanth Sivanathan[SUP] 2 [/SUP], Andreas Schulz[SUP] 4 [/SUP], Niels A W Lemmermann[SUP] 5 [/SUP], Sven Danckwardt[SUP] 1 4 [/SUP], Karl J Lackner[SUP] 1 [/SUP], Peter R Galle[SUP] 2 [/SUP], Inge Scharrer[SUP] 4 [/SUP], Bernhard L?mmle[SUP] 4 6 7 [/SUP], Martin F Sprinzl[SUP] 1 2 3 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease-2019 (COVID-19) triggers systemic infection with involvement of the respiratory tract. There are some patients developing haemostatic abnormalities during their infection with a considerably increased risk of death.
Materials and methods: Patients (n = 85) with SARS-CoV-2 infection attending the University Medical Center, Mainz, from 3 March to 15 May 2020 were retrospectively included in this study. Data regarding demography, clinical features, treatment and laboratory parameters were analyzed. Twenty patients were excluded for assessment of disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) due to lack of laboratory data.
Results: COVID-19 patients (n = 65) were investigated, 19 with uncomplicated, 29 with complicated, and 17 with critical course; nine (13.8%) died. Seven patients showed overt DIC according to the ISTH criteria. The fibrinogen levels dropped significantly in these patients, although not below 100 mg/dl. Hallmarks of TMA, such as thrombocytopenia and microangiopathic haemolytic anaemia, were not detected in any of our COVID-19 patients. ADAMTS13 activity was mildly to moderately reduced in 4/22 patients, all having strongly elevated procalcitonin levels.
Conclusion: DIC occurred in 7/65 COVID-19 patients but fibrinogen and platelet consumption were compensated in almost all. ADAMTS13 assays excluded TTP and hallmarks of classic TMA were absent in all investigated patients. We hypothesize that the lacking erythrocyte fragmentation and only mild platelet consumption in severe COVID-19 are due to a microangiopathy predominantly localized to the alveolar microcirculation with a low blood pressure gradient.
Keywords: ADAMTS13; COVID-19; coronavirus disease; disseminated intravascular coagulation; microangiopathy.
. 2021 Feb 9;10(4):671.
doi: 10.3390/jcm10040671.
No Evidence for Classic Thrombotic Microangiopathy in COVID-19
Tanja Falter[SUP] 1 [/SUP], Heidi Rossmann[SUP] 1 [/SUP], Philipp Menge[SUP] 2 [/SUP], Jan Goetje[SUP] 2 [/SUP], Steffen Groenwoldt[SUP] 2 [/SUP], Arndt Weinmann[SUP] 2 3 [/SUP], Visvakanth Sivanathan[SUP] 2 [/SUP], Andreas Schulz[SUP] 4 [/SUP], Niels A W Lemmermann[SUP] 5 [/SUP], Sven Danckwardt[SUP] 1 4 [/SUP], Karl J Lackner[SUP] 1 [/SUP], Peter R Galle[SUP] 2 [/SUP], Inge Scharrer[SUP] 4 [/SUP], Bernhard L?mmle[SUP] 4 6 7 [/SUP], Martin F Sprinzl[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 33572417
- DOI: 10.3390/jcm10040671
Abstract
Background: Coronavirus disease-2019 (COVID-19) triggers systemic infection with involvement of the respiratory tract. There are some patients developing haemostatic abnormalities during their infection with a considerably increased risk of death.
Materials and methods: Patients (n = 85) with SARS-CoV-2 infection attending the University Medical Center, Mainz, from 3 March to 15 May 2020 were retrospectively included in this study. Data regarding demography, clinical features, treatment and laboratory parameters were analyzed. Twenty patients were excluded for assessment of disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) due to lack of laboratory data.
Results: COVID-19 patients (n = 65) were investigated, 19 with uncomplicated, 29 with complicated, and 17 with critical course; nine (13.8%) died. Seven patients showed overt DIC according to the ISTH criteria. The fibrinogen levels dropped significantly in these patients, although not below 100 mg/dl. Hallmarks of TMA, such as thrombocytopenia and microangiopathic haemolytic anaemia, were not detected in any of our COVID-19 patients. ADAMTS13 activity was mildly to moderately reduced in 4/22 patients, all having strongly elevated procalcitonin levels.
Conclusion: DIC occurred in 7/65 COVID-19 patients but fibrinogen and platelet consumption were compensated in almost all. ADAMTS13 assays excluded TTP and hallmarks of classic TMA were absent in all investigated patients. We hypothesize that the lacking erythrocyte fragmentation and only mild platelet consumption in severe COVID-19 are due to a microangiopathy predominantly localized to the alveolar microcirculation with a low blood pressure gradient.
Keywords: ADAMTS13; COVID-19; coronavirus disease; disseminated intravascular coagulation; microangiopathy.