tetano
Editor, Senior Moderator
J Clin Med. 2020 Apr 1;9(4). pii: E982. doi: 10.3390/jcm9040982.
Master Regulator Analysis of the SARS-CoV-2/Human Interactome.
Guzzi PH[SUP]1[/SUP], Mercatelli D[SUP]2[/SUP], Ceraolo C[SUP]2[/SUP], Giorgi FM[SUP]2[/SUP].
Author information
Abstract
The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.
KEYWORDS:
COVID-19; SARS-CoV-2; bioinformatics; coronavirus; gene network analysis
PMID:32244779DOI:10.3390/jcm9040982
Free full text
Master Regulator Analysis of the SARS-CoV-2/Human Interactome.
Guzzi PH[SUP]1[/SUP], Mercatelli D[SUP]2[/SUP], Ceraolo C[SUP]2[/SUP], Giorgi FM[SUP]2[/SUP].
Author information
Abstract
The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.
KEYWORDS:
COVID-19; SARS-CoV-2; bioinformatics; coronavirus; gene network analysis
PMID:32244779DOI:10.3390/jcm9040982
Free full text