tetano
Editor, Senior Moderator
J Clin Med
. 2021 Dec 14;10(24):5861.
doi: 10.3390/jcm10245861.
Instrumental Evaluation of COVID-19 Related Dysautonomia in Non-Critically-Ill Patients: An Observational, Cross-Sectional Study
Simone Bellavia[SUP] 1 [/SUP], Irene Scala[SUP] 1 [/SUP], Marco Luigetti[SUP] 2 [/SUP], Valerio Brunetti[SUP] 2 [/SUP], Maurizio Gabrielli[SUP] 3 [/SUP], Lorenzo Zileri Dal Verme[SUP] 4 [/SUP], Serenella Servidei[SUP] 1 [/SUP], Paolo Calabresi[SUP] 1 2 [/SUP], Giovanni Frisullo[SUP] 2 [/SUP], Giacomo Della Marca[SUP] 1 2 [/SUP]
Affiliations
Abstract
Coronavirus disease-19 (COVID-19) is a predominantly respiratory syndrome. Growing reports about a SARS-CoV-2 neurological involvement, including autonomic dysfunction (AD), have been reported, mostly in critically-ill patients, or in the long-COVID syndrome. In this observational, cross-sectional study, we investigated the prevalence of AD in 20 non-critically-ill COVID-19 patients (COVID+ group) in the acute phase of the disease through a composite instrumental evaluation consisting of Sudoscan, automated pupillometry, heart rate variability (HRV), and pulse transit time (PTT). All the parameters were compared to a control group of 20 healthy volunteers (COVID- group). COVID+ group presented higher values of pupillary dilatation velocities, and baseline pupil diameter than COVID- subjects. Moreover, COVID+ patients presented a higher incidence of feet sudomotor dysfunction than COVID- group. No significant differences emerged in HRV and PTT parameters between groups. In this study we observed the occurrence of autonomic dysfunction in the early stage of the disease.
Keywords: COVID-19; SARS-CoV-2; Sudoscan; automated pupillometry; autonomic dysfunction; dysautonomia; heart rate variability; pulse transit time.
. 2021 Dec 14;10(24):5861.
doi: 10.3390/jcm10245861.
Instrumental Evaluation of COVID-19 Related Dysautonomia in Non-Critically-Ill Patients: An Observational, Cross-Sectional Study
Simone Bellavia[SUP] 1 [/SUP], Irene Scala[SUP] 1 [/SUP], Marco Luigetti[SUP] 2 [/SUP], Valerio Brunetti[SUP] 2 [/SUP], Maurizio Gabrielli[SUP] 3 [/SUP], Lorenzo Zileri Dal Verme[SUP] 4 [/SUP], Serenella Servidei[SUP] 1 [/SUP], Paolo Calabresi[SUP] 1 2 [/SUP], Giovanni Frisullo[SUP] 2 [/SUP], Giacomo Della Marca[SUP] 1 2 [/SUP]
Affiliations
- PMID: 34945155
- DOI: 10.3390/jcm10245861
Abstract
Coronavirus disease-19 (COVID-19) is a predominantly respiratory syndrome. Growing reports about a SARS-CoV-2 neurological involvement, including autonomic dysfunction (AD), have been reported, mostly in critically-ill patients, or in the long-COVID syndrome. In this observational, cross-sectional study, we investigated the prevalence of AD in 20 non-critically-ill COVID-19 patients (COVID+ group) in the acute phase of the disease through a composite instrumental evaluation consisting of Sudoscan, automated pupillometry, heart rate variability (HRV), and pulse transit time (PTT). All the parameters were compared to a control group of 20 healthy volunteers (COVID- group). COVID+ group presented higher values of pupillary dilatation velocities, and baseline pupil diameter than COVID- subjects. Moreover, COVID+ patients presented a higher incidence of feet sudomotor dysfunction than COVID- group. No significant differences emerged in HRV and PTT parameters between groups. In this study we observed the occurrence of autonomic dysfunction in the early stage of the disease.
Keywords: COVID-19; SARS-CoV-2; Sudoscan; automated pupillometry; autonomic dysfunction; dysautonomia; heart rate variability; pulse transit time.