tetano
Editor, Senior Moderator
J Clin Med
. 2022 Aug 30;11(17):5106.
doi: 10.3390/jcm11175106.
Hyperglycemia and Hypoglycemia Are Associated with In-Hospital Mortality among Patients with Coronavirus Disease 2019 Supported with Extracorporeal Membrane Oxygenation
Kuk Hui Son[SUP] 1 [/SUP], Woong-Han Kim[SUP] 2 [/SUP], Jae Gun Kwak[SUP] 2 [/SUP], Chang-Hyu Choi[SUP] 1 [/SUP], Seok In Lee[SUP] 1 [/SUP], Ui Won Ko[SUP] 3 [/SUP], Hyoung Soo Kim[SUP] 4 [/SUP], Haeyoung Lee[SUP] 5 [/SUP], Euy Suk Chung[SUP] 6 [/SUP], Jae-Bum Kim[SUP] 7 [/SUP], Woo Sung Jang[SUP] 7 [/SUP], Jae Seung Jung[SUP] 8 [/SUP], Jieon Kim[SUP] 8 [/SUP], Young Kyung Yoon[SUP] 9 [/SUP], Seunghwan Song[SUP] 10 [/SUP], Minji Sung[SUP] 11 [/SUP], Myung Hun Jang[SUP] 12 [/SUP], Young Sam Kim[SUP] 13 [/SUP], In-Seok Jeong[SUP] 14 [/SUP], Do Wan Kim[SUP] 14 [/SUP], Tae Yun Kim[SUP] 15 [/SUP], Soon Jin Kim[SUP] 15 [/SUP], Su Wan Kim[SUP] 16 [/SUP], Joonhwa Hong[SUP] 17 [/SUP], Hyungmi An[SUP] 18 [/SUP], On Behalf Of The Korean Society For Thoracic And Cardiovascular Surgery Covid-Ecmo Task Force Team
Affiliations
Abstract
Metabolic abnormalities, such as preexisting diabetes or hyperglycemia or hypoglycemia during hospitalization aggravated the severity of COVID-19. We evaluated whether diabetes history, hyperglycemia before and during extracorporeal membrane oxygenation (ECMO) support, and hypoglycemia were risk factors for mortality in patients with COVID-19. This study included data on 195 patients with COVID-19, who were aged ≥19 years and were treated with ECMO. The proportion of patients with diabetes history among nonsurvivors was higher than that among survivors. Univariate Cox regression analysis showed that in-hospital mortality after ECMO support was associated with diabetes history, renal replacement therapy (RRT), and body mass index (BMI) < 18.5 kg/m[SUP]2[/SUP]. Glucose at admission >200 mg/dL and glucose levels before ventilator >200 mg/dL were not associated with in-hospital mortality. However, glucose levels before ECMO >200 mg/dL and minimal glucose levels during hospitalization <70 mg/dL were associated with in-hospital mortality. Multivariable Cox regression analysis showed that glucose >200 mg/dL before ECMO and minimal glucose <70 mg/dL during hospitalization remained risk factors for in-hospital mortality after adjustment for age, BMI, and RRT. In conclusion, glucose >200 mg/dL before ECMO and minimal glucose level <70 mg/dL during hospitalization were risk factors for in-hospital mortality among COVID-19 patients who underwent ECMO.
Keywords: COVID-19; diabetes; extracorporeal membrane; hyperglycemia; hypoglycemia.
. 2022 Aug 30;11(17):5106.
doi: 10.3390/jcm11175106.
Hyperglycemia and Hypoglycemia Are Associated with In-Hospital Mortality among Patients with Coronavirus Disease 2019 Supported with Extracorporeal Membrane Oxygenation
Kuk Hui Son[SUP] 1 [/SUP], Woong-Han Kim[SUP] 2 [/SUP], Jae Gun Kwak[SUP] 2 [/SUP], Chang-Hyu Choi[SUP] 1 [/SUP], Seok In Lee[SUP] 1 [/SUP], Ui Won Ko[SUP] 3 [/SUP], Hyoung Soo Kim[SUP] 4 [/SUP], Haeyoung Lee[SUP] 5 [/SUP], Euy Suk Chung[SUP] 6 [/SUP], Jae-Bum Kim[SUP] 7 [/SUP], Woo Sung Jang[SUP] 7 [/SUP], Jae Seung Jung[SUP] 8 [/SUP], Jieon Kim[SUP] 8 [/SUP], Young Kyung Yoon[SUP] 9 [/SUP], Seunghwan Song[SUP] 10 [/SUP], Minji Sung[SUP] 11 [/SUP], Myung Hun Jang[SUP] 12 [/SUP], Young Sam Kim[SUP] 13 [/SUP], In-Seok Jeong[SUP] 14 [/SUP], Do Wan Kim[SUP] 14 [/SUP], Tae Yun Kim[SUP] 15 [/SUP], Soon Jin Kim[SUP] 15 [/SUP], Su Wan Kim[SUP] 16 [/SUP], Joonhwa Hong[SUP] 17 [/SUP], Hyungmi An[SUP] 18 [/SUP], On Behalf Of The Korean Society For Thoracic And Cardiovascular Surgery Covid-Ecmo Task Force Team
Affiliations
- PMID: 36079032
- DOI: 10.3390/jcm11175106
Abstract
Metabolic abnormalities, such as preexisting diabetes or hyperglycemia or hypoglycemia during hospitalization aggravated the severity of COVID-19. We evaluated whether diabetes history, hyperglycemia before and during extracorporeal membrane oxygenation (ECMO) support, and hypoglycemia were risk factors for mortality in patients with COVID-19. This study included data on 195 patients with COVID-19, who were aged ≥19 years and were treated with ECMO. The proportion of patients with diabetes history among nonsurvivors was higher than that among survivors. Univariate Cox regression analysis showed that in-hospital mortality after ECMO support was associated with diabetes history, renal replacement therapy (RRT), and body mass index (BMI) < 18.5 kg/m[SUP]2[/SUP]. Glucose at admission >200 mg/dL and glucose levels before ventilator >200 mg/dL were not associated with in-hospital mortality. However, glucose levels before ECMO >200 mg/dL and minimal glucose levels during hospitalization <70 mg/dL were associated with in-hospital mortality. Multivariable Cox regression analysis showed that glucose >200 mg/dL before ECMO and minimal glucose <70 mg/dL during hospitalization remained risk factors for in-hospital mortality after adjustment for age, BMI, and RRT. In conclusion, glucose >200 mg/dL before ECMO and minimal glucose level <70 mg/dL during hospitalization were risk factors for in-hospital mortality among COVID-19 patients who underwent ECMO.
Keywords: COVID-19; diabetes; extracorporeal membrane; hyperglycemia; hypoglycemia.