tetano
Editor, Senior Moderator
J Clin Med
. 2024 Nov 28;13(23):7242.
doi: 10.3390/jcm13237242. High-Density Lipoprotein Predicts Intrahospital Mortality in Influenza
Matthias Wolfgang Heinzl[SUP] 1 2 [/SUP], Markus Freudenthaler[SUP] 1 3 [/SUP], Paul Fellinger[SUP] 4 [/SUP], Lisa Kolenchery[SUP] 1 2 [/SUP], Michael Resl[SUP] 1 2 [/SUP], Carmen Klammer[SUP] 1 2 [/SUP], Florian Obendorf[SUP] 1 [/SUP], Lukas Schinagl[SUP] 1 [/SUP], Thomas Berger[SUP] 1 [/SUP], Margot Egger[SUP] 3 5 [/SUP], Benjamin Dieplinger[SUP] 3 [/SUP], Martin Clodi[SUP] 1 2 3 [/SUP]
Affiliations
Background: Although it is known that high-density lipoprotein (HDL) exerts important anti-inflammatory effects and that low HDL plasma concentrations represent a negative prognostic marker in bacterial infections and sepsis, not much is known about possible implications of HDL in acute viral infections such as influenza. Methods: We performed a retrospective, single-centre analysis of influenza patients hospitalised during the 2018/19 and 2019/20 influenza seasons and analysed the impact of HDL concentrations on inflammation and mortality. Results: 199 influenza patients (173 male patients) were admitted during the 2018/19 and 2019/20 influenza seasons with a mortality rate of 4.5%. HDL was significantly lower in deceased patients (median HDL 21 (IQR 19-25) vs. 35 (IQR 28-44) mg/dL; p = 0.005). Low HDL correlated with increased inflammation and HDL was an independent negative predictor regarding mortality after correction for age and the number of comorbidities both overall (OR = 0.890; p = 0.008) and in male patients only (OR = 0.891; p = 0.009). Conclusions: Low HDL upon hospital admission is associated with increased inflammation and is an independent predictor for increased mortality in male patients with influenza A.
Keywords: HDL; acute viral infection; anti-inflammatory; influenza; lipid scavenging; lipoproteins.
. 2024 Nov 28;13(23):7242.
doi: 10.3390/jcm13237242. High-Density Lipoprotein Predicts Intrahospital Mortality in Influenza
Matthias Wolfgang Heinzl[SUP] 1 2 [/SUP], Markus Freudenthaler[SUP] 1 3 [/SUP], Paul Fellinger[SUP] 4 [/SUP], Lisa Kolenchery[SUP] 1 2 [/SUP], Michael Resl[SUP] 1 2 [/SUP], Carmen Klammer[SUP] 1 2 [/SUP], Florian Obendorf[SUP] 1 [/SUP], Lukas Schinagl[SUP] 1 [/SUP], Thomas Berger[SUP] 1 [/SUP], Margot Egger[SUP] 3 5 [/SUP], Benjamin Dieplinger[SUP] 3 [/SUP], Martin Clodi[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 39685701
- DOI: 10.3390/jcm13237242
Background: Although it is known that high-density lipoprotein (HDL) exerts important anti-inflammatory effects and that low HDL plasma concentrations represent a negative prognostic marker in bacterial infections and sepsis, not much is known about possible implications of HDL in acute viral infections such as influenza. Methods: We performed a retrospective, single-centre analysis of influenza patients hospitalised during the 2018/19 and 2019/20 influenza seasons and analysed the impact of HDL concentrations on inflammation and mortality. Results: 199 influenza patients (173 male patients) were admitted during the 2018/19 and 2019/20 influenza seasons with a mortality rate of 4.5%. HDL was significantly lower in deceased patients (median HDL 21 (IQR 19-25) vs. 35 (IQR 28-44) mg/dL; p = 0.005). Low HDL correlated with increased inflammation and HDL was an independent negative predictor regarding mortality after correction for age and the number of comorbidities both overall (OR = 0.890; p = 0.008) and in male patients only (OR = 0.891; p = 0.009). Conclusions: Low HDL upon hospital admission is associated with increased inflammation and is an independent predictor for increased mortality in male patients with influenza A.
Keywords: HDL; acute viral infection; anti-inflammatory; influenza; lipid scavenging; lipoproteins.