tetano
Editor, Senior Moderator
J Clin Med
. 2024 Mar 27;13(7):1938.
doi: 10.3390/jcm13071938. Delayed Antibody Response in the Acute Phase of Infection Is Associated with a Lower Mental Component of Quality of Life in Survivors of Severe and Critical COVID-19
Mohammad Mahmud Otman Dababseh[SUP] 1 [/SUP], Peter Sabaka[SUP] 1 [/SUP], Oľga Duraníková[SUP] 2 [/SUP], Simona Horváthová[SUP] 2 [/SUP], Peter Valkovič[SUP] 2 3 [/SUP], Igor Straka[SUP] 2 [/SUP], Anna Nagyová[SUP] 1 [/SUP], Vladimír Boža[SUP] 4 [/SUP], Marián Kravec[SUP] 4 [/SUP], Ján Jurenka[SUP] 1 [/SUP], Alena Koščálová[SUP] 5 [/SUP], Peter Mihalov[SUP] 1 [/SUP], Eliška Marešová[SUP] 1 [/SUP], Matej Bendžala[SUP] 1 [/SUP], Alice Kušnírová[SUP] 2 [/SUP], Igor Stankovič[SUP] 1 [/SUP]
Affiliations
Background: The long-term sequelae of coronavirus disease 2019 (COVID-19) significantly affects quality of life (QoL) in disease survivors. Delayed development of the adaptive immune response is associated with more severe disease and a worse prognosis in COVID-19. The effects of delayed immune response on COVID-19 sequelae and QoL are unknown. Methods: We conducted a prospective study to assess the relationship between the delayed antibody response in the acute phase of infection in naïve unvaccinated patients suffering from severe or critical COVID-19 and their QoL 12 months after hospital discharge. The 12-item Short Form Survey (SF-12) questionnaire was used for assessment of QoL. The SF-12 evaluates both mental and physical components of QoL, incorporating a mental component score (MCS-12) and a physical component score (PCS-12). A delayed antibody response was defined as testing negative for anti-spike SARS-CoV-2 antibodies at the time of hospital admission. Results: The study included 274 patients (154 men and 120 women). Of the enrolled patients, 144 had a delayed immune response. These patients had a significantly lower MCS-12 (p = 0.002), but PCS-12 (p = 0.397) was not significantly different at the 12-month follow-up compared to patients with positive anti-spike SARS-CoV-2 antibodies. The MCS-12 at the time of follow-up was negatively associated with delayed antibody response irrespective of possible confounders (p = 0.006; B = 3.609; ηp2 = 0.035; 95% CI = 1.069-6.150). An MSC-12 below 50 points at the time of follow-up was positively associated with delayed antibody response (p = 0.001; B = 1.092; OR = 2.979; 95% CI = 1.554-5.711). Conclusions: This study confirmed that, in patients with severe and critical COVID-19, a negative result for anti-spike SARS-CoV-2 antibodies at the time of hospital admission is associated with a lower mental component of QoL in unvaccinated patients naïve to COVID-19 one year after hospital discharge.
Keywords: COVID-19; anti-spike SARS-CoV-2 antibodies; delayed antibody response; mental health; quality of life.
. 2024 Mar 27;13(7):1938.
doi: 10.3390/jcm13071938. Delayed Antibody Response in the Acute Phase of Infection Is Associated with a Lower Mental Component of Quality of Life in Survivors of Severe and Critical COVID-19
Mohammad Mahmud Otman Dababseh[SUP] 1 [/SUP], Peter Sabaka[SUP] 1 [/SUP], Oľga Duraníková[SUP] 2 [/SUP], Simona Horváthová[SUP] 2 [/SUP], Peter Valkovič[SUP] 2 3 [/SUP], Igor Straka[SUP] 2 [/SUP], Anna Nagyová[SUP] 1 [/SUP], Vladimír Boža[SUP] 4 [/SUP], Marián Kravec[SUP] 4 [/SUP], Ján Jurenka[SUP] 1 [/SUP], Alena Koščálová[SUP] 5 [/SUP], Peter Mihalov[SUP] 1 [/SUP], Eliška Marešová[SUP] 1 [/SUP], Matej Bendžala[SUP] 1 [/SUP], Alice Kušnírová[SUP] 2 [/SUP], Igor Stankovič[SUP] 1 [/SUP]
Affiliations
- PMID: 38610703
- PMCID: PMC11012816
- DOI: 10.3390/jcm13071938
Background: The long-term sequelae of coronavirus disease 2019 (COVID-19) significantly affects quality of life (QoL) in disease survivors. Delayed development of the adaptive immune response is associated with more severe disease and a worse prognosis in COVID-19. The effects of delayed immune response on COVID-19 sequelae and QoL are unknown. Methods: We conducted a prospective study to assess the relationship between the delayed antibody response in the acute phase of infection in naïve unvaccinated patients suffering from severe or critical COVID-19 and their QoL 12 months after hospital discharge. The 12-item Short Form Survey (SF-12) questionnaire was used for assessment of QoL. The SF-12 evaluates both mental and physical components of QoL, incorporating a mental component score (MCS-12) and a physical component score (PCS-12). A delayed antibody response was defined as testing negative for anti-spike SARS-CoV-2 antibodies at the time of hospital admission. Results: The study included 274 patients (154 men and 120 women). Of the enrolled patients, 144 had a delayed immune response. These patients had a significantly lower MCS-12 (p = 0.002), but PCS-12 (p = 0.397) was not significantly different at the 12-month follow-up compared to patients with positive anti-spike SARS-CoV-2 antibodies. The MCS-12 at the time of follow-up was negatively associated with delayed antibody response irrespective of possible confounders (p = 0.006; B = 3.609; ηp2 = 0.035; 95% CI = 1.069-6.150). An MSC-12 below 50 points at the time of follow-up was positively associated with delayed antibody response (p = 0.001; B = 1.092; OR = 2.979; 95% CI = 1.554-5.711). Conclusions: This study confirmed that, in patients with severe and critical COVID-19, a negative result for anti-spike SARS-CoV-2 antibodies at the time of hospital admission is associated with a lower mental component of QoL in unvaccinated patients naïve to COVID-19 one year after hospital discharge.
Keywords: COVID-19; anti-spike SARS-CoV-2 antibodies; delayed antibody response; mental health; quality of life.