tetano
Editor, Senior Moderator
J Clin Med
. 2022 Jun 24;11(13):3651.
doi: 10.3390/jcm11133651.
Collapsing Glomerulonephritis in a Kidney Transplant Recipient after mRNA SARS-CoV-2 Vaccination
Francisco Gómez Preciado[SUP] 1 [/SUP], Rosa Alejandra De Carvalho Ovalles[SUP] 2 [/SUP], Sergi Codina[SUP] 1 [/SUP], Laura Donadeu[SUP] 3 [/SUP], Alexandre Favà[SUP] 1 [/SUP], Laura Martinez Valenzuela[SUP] 1 [/SUP], Diego Sandoval[SUP] 1 [/SUP], Bárbara Fernández-Cidón[SUP] 4 [/SUP], Oriol Bestard[SUP] 5 [/SUP], Pedro Alia-Ramos[SUP] 4 [/SUP], Montserrat Gomà[SUP] 2 [/SUP], Edoardo Melilli[SUP] 1 6 [/SUP], Josep M Cruzado[SUP] 1 6 7 [/SUP]
Affiliations
Abstract
With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mRNA vaccination against SARS-CoV-2, developed nephrotic proteinuria and renal dysfunction, with a biopsy diagnostic of collapsing glomerulonephritis. No other triggers for this glomerulonephritis were identified. Antibodies against the spike protein were negative, but the patient developed a specific T-cell response. The close time between vaccination and the proteinuria suggests a possible determinant role of vaccination. We should be aware of nephropathies appearing after COVID-19 vaccination in kidney transplant recipients also.
Keywords: COVID-19; SARS-CoV-2; collapsing; glomerulonephritis; mRNA; vaccine.
. 2022 Jun 24;11(13):3651.
doi: 10.3390/jcm11133651.
Collapsing Glomerulonephritis in a Kidney Transplant Recipient after mRNA SARS-CoV-2 Vaccination
Francisco Gómez Preciado[SUP] 1 [/SUP], Rosa Alejandra De Carvalho Ovalles[SUP] 2 [/SUP], Sergi Codina[SUP] 1 [/SUP], Laura Donadeu[SUP] 3 [/SUP], Alexandre Favà[SUP] 1 [/SUP], Laura Martinez Valenzuela[SUP] 1 [/SUP], Diego Sandoval[SUP] 1 [/SUP], Bárbara Fernández-Cidón[SUP] 4 [/SUP], Oriol Bestard[SUP] 5 [/SUP], Pedro Alia-Ramos[SUP] 4 [/SUP], Montserrat Gomà[SUP] 2 [/SUP], Edoardo Melilli[SUP] 1 6 [/SUP], Josep M Cruzado[SUP] 1 6 7 [/SUP]
Affiliations
- PMID: 35806939
- DOI: 10.3390/jcm11133651
Abstract
With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mRNA vaccination against SARS-CoV-2, developed nephrotic proteinuria and renal dysfunction, with a biopsy diagnostic of collapsing glomerulonephritis. No other triggers for this glomerulonephritis were identified. Antibodies against the spike protein were negative, but the patient developed a specific T-cell response. The close time between vaccination and the proteinuria suggests a possible determinant role of vaccination. We should be aware of nephropathies appearing after COVID-19 vaccination in kidney transplant recipients also.
Keywords: COVID-19; SARS-CoV-2; collapsing; glomerulonephritis; mRNA; vaccine.