tetano
Editor, Senior Moderator
J Clin Med
. 2020 Nov 11;9(11):E3630.
doi: 10.3390/jcm9113630.
Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19
Keiichi Mitsuyama[SUP] 1 2 [/SUP], Kozo Tsuruta[SUP] 1 2 [/SUP], Hidetoshi Takedatsu[SUP] 1 2 [/SUP], Shinichiro Yoshioka[SUP] 1 2 [/SUP], Masaru Morita[SUP] 1 2 [/SUP], Mikio Niwa[SUP] 3 [/SUP], Satoshi Matsumoto[SUP] 4 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route for virus transmission, most likely due to the presence of angiotensin-converting enzyme 2. Therefore, understanding the mechanisms of GI injury is crucial for a harmonized therapeutic strategy against COVID-19. This review summarizes the current evidence for the clinical features of and possible pathogenic mechanisms leading to GI injury in COVID-19.
Keywords: ACE2; COVID-19; SARS-CoV-2; TMPRSS2; gastrointestinal tract; gut microbiota; intestine; renin-angiotensin-aldosterone system; thrombosis; tryptophan.
. 2020 Nov 11;9(11):E3630.
doi: 10.3390/jcm9113630.
Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19
Keiichi Mitsuyama[SUP] 1 2 [/SUP], Kozo Tsuruta[SUP] 1 2 [/SUP], Hidetoshi Takedatsu[SUP] 1 2 [/SUP], Shinichiro Yoshioka[SUP] 1 2 [/SUP], Masaru Morita[SUP] 1 2 [/SUP], Mikio Niwa[SUP] 3 [/SUP], Satoshi Matsumoto[SUP] 4 [/SUP]
Affiliations
- PMID: 33187280
- DOI: 10.3390/jcm9113630
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route for virus transmission, most likely due to the presence of angiotensin-converting enzyme 2. Therefore, understanding the mechanisms of GI injury is crucial for a harmonized therapeutic strategy against COVID-19. This review summarizes the current evidence for the clinical features of and possible pathogenic mechanisms leading to GI injury in COVID-19.
Keywords: ACE2; COVID-19; SARS-CoV-2; TMPRSS2; gastrointestinal tract; gut microbiota; intestine; renin-angiotensin-aldosterone system; thrombosis; tryptophan.