tetano
Editor, Senior Moderator
J Clin Lab Anal
. 2021 Nov 5;e24088.
doi: 10.1002/jcla.24088. Online ahead of print.
Clinical and biochemical indexes of 11 COVID-19 patients and the genome sequence analysis of the tested SARS-CoV-2
Zhikang Yu[SUP] 1 2 3 [/SUP], Heming Wu[SUP] 1 2 3 [/SUP], Qingyan Huang[SUP] 1 2 3 [/SUP], Zhixiong Zhong[SUP] 1 2 3 [/SUP]
Affiliations
Abstract
Background: At present, SARS-CoV-2 epidemic in the world rapidly spread. It is a serious global public health emergency.
Methods: In this study, we described the clinical characteristics of 11 COVID-19 patients hospitalized in the Meizhou People's Hospital, and viral genome sequences of SARS-CoV-2 from these patients were analyzed.
Results: Of the 11 patients, six cases developed fever, 9 cases developed a cough, and two cases developed headache and chills. Four patients (36.4%) had underlying diseases. Pneumonia is the most common complication. The laboratory test results showed that there were no adult patients with increased lymphocyte/lymphocyte percentage (LYM/LYM%). Most patients had normal total protein (TP) and albumin (ALB), but only two patients had decreased. Most patients had increased or normal levels of erythrocyte sedimentation rate (ESR), C reactive protein (CRP), activated partial thromboplastin time (APTT), fibrinogen (FIB), creatine kinase isoenzymes (CK-MB), and lactate dehydrogenase (LDH). Neutrophil (NEU) (r = 0.664, p = 0.026), CK-MB (r = 0.655, p = 0.029) and blood urea nitrogen (BUN) (r = 0.682, p = 0.021) were significantly associated with SARS-CoV-2 virus cycle threshold (Ct) value. Multiple sequence alignment (MSA) shows that two different SNPs were identified at positions 8781 and 28144, and have a complete linkage genetic form of 8781C-28144T and 8781T-28144C.
Conclusions: The reports of the 11 COVID-19 patients in our hospital will provide useful information for the diagnosis, treatment, and drug development of SARS-CoV-2.
Keywords: COVID-19; Meizhou; SARS-CoV-2; novel coronavirus pneumonia.
. 2021 Nov 5;e24088.
doi: 10.1002/jcla.24088. Online ahead of print.
Clinical and biochemical indexes of 11 COVID-19 patients and the genome sequence analysis of the tested SARS-CoV-2
Zhikang Yu[SUP] 1 2 3 [/SUP], Heming Wu[SUP] 1 2 3 [/SUP], Qingyan Huang[SUP] 1 2 3 [/SUP], Zhixiong Zhong[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 34741347
- DOI: 10.1002/jcla.24088
Abstract
Background: At present, SARS-CoV-2 epidemic in the world rapidly spread. It is a serious global public health emergency.
Methods: In this study, we described the clinical characteristics of 11 COVID-19 patients hospitalized in the Meizhou People's Hospital, and viral genome sequences of SARS-CoV-2 from these patients were analyzed.
Results: Of the 11 patients, six cases developed fever, 9 cases developed a cough, and two cases developed headache and chills. Four patients (36.4%) had underlying diseases. Pneumonia is the most common complication. The laboratory test results showed that there were no adult patients with increased lymphocyte/lymphocyte percentage (LYM/LYM%). Most patients had normal total protein (TP) and albumin (ALB), but only two patients had decreased. Most patients had increased or normal levels of erythrocyte sedimentation rate (ESR), C reactive protein (CRP), activated partial thromboplastin time (APTT), fibrinogen (FIB), creatine kinase isoenzymes (CK-MB), and lactate dehydrogenase (LDH). Neutrophil (NEU) (r = 0.664, p = 0.026), CK-MB (r = 0.655, p = 0.029) and blood urea nitrogen (BUN) (r = 0.682, p = 0.021) were significantly associated with SARS-CoV-2 virus cycle threshold (Ct) value. Multiple sequence alignment (MSA) shows that two different SNPs were identified at positions 8781 and 28144, and have a complete linkage genetic form of 8781C-28144T and 8781T-28144C.
Conclusions: The reports of the 11 COVID-19 patients in our hospital will provide useful information for the diagnosis, treatment, and drug development of SARS-CoV-2.
Keywords: COVID-19; Meizhou; SARS-CoV-2; novel coronavirus pneumonia.