tetano
Editor, Senior Moderator
J Clin Invest
. 2020 Sep 30;143380.
doi: 10.1172/JCI143380. Online ahead of print.
Recent endemic coronavirus infection is associated with less severe COVID-19
Manish Sagar[SUP] 1 [/SUP], Katherine Reifler[SUP] 1 [/SUP], Michael Rossi[SUP] 1 [/SUP], Nancy S Miller[SUP] 2 [/SUP], Pranay Sinha[SUP] 1 [/SUP], Laura White[SUP] 3 [/SUP], Joseph P Mizgerd[SUP] 1 [/SUP]
Affiliations
Abstract
Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal "common cold," and these eCoVs share extensive sequence homology with human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we show that individuals with as compared to without a relatively recent documented eCoV were tested at greater frequency for respiratory infections but had similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less severe coronavirus disease-2019 (COVID-19) illness. Our observations suggest that pre-existing immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.
Keywords: Adaptive immunity; COVID-19; Cellular immune response.
. 2020 Sep 30;143380.
doi: 10.1172/JCI143380. Online ahead of print.
Recent endemic coronavirus infection is associated with less severe COVID-19
Manish Sagar[SUP] 1 [/SUP], Katherine Reifler[SUP] 1 [/SUP], Michael Rossi[SUP] 1 [/SUP], Nancy S Miller[SUP] 2 [/SUP], Pranay Sinha[SUP] 1 [/SUP], Laura White[SUP] 3 [/SUP], Joseph P Mizgerd[SUP] 1 [/SUP]
Affiliations
- PMID: 32997649
- DOI: 10.1172/JCI143380
Abstract
Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal "common cold," and these eCoVs share extensive sequence homology with human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we show that individuals with as compared to without a relatively recent documented eCoV were tested at greater frequency for respiratory infections but had similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less severe coronavirus disease-2019 (COVID-19) illness. Our observations suggest that pre-existing immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.
Keywords: Adaptive immunity; COVID-19; Cellular immune response.