tetano
Editor, Senior Moderator
J Clin Endocrinol Metab
. 2023 Apr 25;dgad235.
doi: 10.1210/clinem/dgad235. Online ahead of print. Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study
Adnan Batman[SUP] 1 [/SUP], Dilek Yazici[SUP] 1 [/SUP], Oguz Dikbas[SUP] 2 [/SUP], Kemal Agbaht[SUP] 3 [/SUP], Emre Sedar Saygili[SUP] 4 [/SUP], Ibrahim Demirci[SUP] 5 [/SUP], Nurbanu Bursa[SUP] 6 [/SUP], Görkem Ayas[SUP] 7 [/SUP], Cüneyd Anıl[SUP] 8 [/SUP], Mustafa Cesur[SUP] 8 [/SUP], Fatma Nur Korkmaz[SUP] 9 [/SUP], Adile Begüm Bahçecioglu[SUP] 9 [/SUP], Demet Corapcıoglu[SUP] 9 [/SUP], Murat Faik Erdogan[SUP] 9 [/SUP], Hayri Bostan[SUP] 10 [/SUP], Murat Calapkulu[SUP] 10 [/SUP], Sema Hepsen[SUP] 10 [/SUP], Bekir Ucan[SUP] 10 [/SUP], Erman Cakal[SUP] 10 [/SUP], Bagdagul Yuksel Guler[SUP] 5 [/SUP], Cem Haymana[SUP] 5 [/SUP], Suleyman Hilmi Ipekci[SUP] 11 [/SUP], Selami Aydın[SUP] 12 [/SUP], Havva Sezer[SUP] 1 [/SUP], Seçil Ozısık[SUP] 1 [/SUP], Oguzhan Deyneli[SUP] 1 [/SUP], Faruk Alagol[SUP] 13 [/SUP], Refik Tanakol[SUP] 13 [/SUP], Mustafa Eroglu[SUP] 14 [/SUP], Ummu Mutlu[SUP] 15 [/SUP], Hulya Hacisahinogullari[SUP] 15 [/SUP], Ayse Kubat Uzum[SUP] 15 [/SUP], Canan Demir[SUP] 16 [/SUP], Gonul Koç[SUP] 17 [/SUP], Sevde Nur Fırat[SUP] 17 [/SUP], Tulay Omma[SUP] 18 [/SUP], Nurcan Ince[SUP] 19 [/SUP], Şefika Burcak Polat[SUP] 19 [/SUP], Oya Topaloglu[SUP] 19 [/SUP], Cevdet Aydın[SUP] 19 [/SUP], Bekir Cakır[SUP] 19 [/SUP], Cigdem Tura Bahadır[SUP] 20 [/SUP], Mehmet Guven[SUP] 21 [/SUP], Mehmet Sözen[SUP] 22 [/SUP], Alev Selek[SUP] 22 [/SUP], Zeynep Canturk[SUP] 22 [/SUP], Berrin Cetinarslan[SUP] 22 [/SUP], Mustafa Aydemir[SUP] 23 [/SUP], Isilay Taskaldiran[SUP] 24 [/SUP], Yusuf Bozkus[SUP] 24 [/SUP], Özlem Turhan Iyidir[SUP] 24 [/SUP], Filiz Eksi Haydardedeoglu[SUP] 25 [/SUP], Seda Erem Basmaz[SUP] 26 [/SUP], Mehmet Cagri Unal[SUP] 27 [/SUP], Tevfik Demir[SUP] 27 [/SUP], Ayten Oguz[SUP] 28 [/SUP], Ozlem Celik[SUP] 29 [/SUP], Merve Yilmaz[SUP] 30 [/SUP], Aykut Cimsir[SUP] 10 [/SUP], Serdar Kayihan[SUP] 10 [/SUP], Ziynet Alphan Uc[SUP] 31 [/SUP], Sakin Tekin[SUP] 32 [/SUP], Ömercan Topaloglu[SUP] 33 [/SUP], Basak Ozgen Saydam[SUP] 34 [/SUP], Yasemin Aydogan Unsal[SUP] 34 [/SUP], Ozge Ozer[SUP] 35 [/SUP], Goknur Yorulmaz[SUP] 35 [/SUP], Kader Ugur[SUP] 36 [/SUP], Sezin Dogan Cakir[SUP] 37 [/SUP], Mehmet Asik[SUP] 38 [/SUP], Mustafa Unubol[SUP] 39 [/SUP], Selin Genc[SUP] 40 [/SUP], Burak Andac[SUP] 41 [/SUP], Mine Okur[SUP] 41 [/SUP], Ozlem Dogan[SUP] 42 [/SUP], Ersen Karakiliç[SUP] 43 [/SUP], Gokcen Unal Kocabas[SUP] 44 [/SUP], Cem Onur Kirac[SUP] 45 [/SUP], Guven Baris Cansu[SUP] 46 [/SUP], Meliha Melin Uygur[SUP] 47 [/SUP], Zafer Pekkolay[SUP] 48 [/SUP], Sadettin Ozturk[SUP] 49 [/SUP], Askin Gungunes[SUP] 50 [/SUP], Eren Gurkan[SUP] 51 [/SUP], Lezzan Keskin[SUP] 52 [/SUP], Kenan Caglayan[SUP] 53 [/SUP], Yasemin Emur Gunay[SUP] 54 [/SUP], Eren İmre[SUP] 55 [/SUP], Selcuk Yusuf Sener[SUP] 56 [/SUP], Ahmet Toygar Kalkan[SUP] 57 [/SUP], Deniz Engin Gok[SUP] 58 [/SUP], Mustafa Sahin[SUP] 9 [/SUP]
Affiliations
Background/aim: The aims of the study are to compare characteristics of subacute thyroiditis (SAT) related to different aetiologies, and to identify predictors of recurrence of SAT and incident hypothyroidism.
Methods: This nationwide multicenter retrospective cohort study included 53 endocrinology centers in Turkey. The study participants were divided into either coronavirus disease-2019 (COVID-19)-related SAT (Cov-SAT), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related SAT (Vac-SAT), or control SAT (Cont-SAT).
Results: Of the 811 patients, 258 (31·8%) were included in the Vac-SAT group, 98 (12·1%) in the Cov-SAT group, and 455 (56·1%) in the Cont-SAT group. No difference was found between the groups with regard to laboratory and imaging findings. The aetiology of SAT was not an independent predictor of recurrence or hypothyroidism. In the entire cohort, steroid therapy requirement and younger age were statistically significant predictors for SAT recurrence. C-reactive protein (CRP) measured during SAT onset, female gender, absence of anti-thyroid peroxidase (TPO) positivity, and absence of steroid therapy were statistically significant predictors of incident (early) hypothyroidism, irrespective of SAT aetiology. On the other hand, probable predictors of established hypothyroidism differed from that of incident hypothyroidism.
Conclusion: Since there is no difference in terms of follow-up parameters and outcomes, COVID-19- and SARS-CoV-2- vaccine related SATs can be treated and followed up like classical SATs. The recurrence was determined by the younger age and steroid therapy requirement. Steroid therapy independently predict incident hypothyroidism that may sometimes be transient in overall SATs and is also associated with lower risk of established hypothyroidism.
Keywords: COVID-19; SARS-CoV-2 vaccine; subacute thyroiditis.
. 2023 Apr 25;dgad235.
doi: 10.1210/clinem/dgad235. Online ahead of print. Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study
Adnan Batman[SUP] 1 [/SUP], Dilek Yazici[SUP] 1 [/SUP], Oguz Dikbas[SUP] 2 [/SUP], Kemal Agbaht[SUP] 3 [/SUP], Emre Sedar Saygili[SUP] 4 [/SUP], Ibrahim Demirci[SUP] 5 [/SUP], Nurbanu Bursa[SUP] 6 [/SUP], Görkem Ayas[SUP] 7 [/SUP], Cüneyd Anıl[SUP] 8 [/SUP], Mustafa Cesur[SUP] 8 [/SUP], Fatma Nur Korkmaz[SUP] 9 [/SUP], Adile Begüm Bahçecioglu[SUP] 9 [/SUP], Demet Corapcıoglu[SUP] 9 [/SUP], Murat Faik Erdogan[SUP] 9 [/SUP], Hayri Bostan[SUP] 10 [/SUP], Murat Calapkulu[SUP] 10 [/SUP], Sema Hepsen[SUP] 10 [/SUP], Bekir Ucan[SUP] 10 [/SUP], Erman Cakal[SUP] 10 [/SUP], Bagdagul Yuksel Guler[SUP] 5 [/SUP], Cem Haymana[SUP] 5 [/SUP], Suleyman Hilmi Ipekci[SUP] 11 [/SUP], Selami Aydın[SUP] 12 [/SUP], Havva Sezer[SUP] 1 [/SUP], Seçil Ozısık[SUP] 1 [/SUP], Oguzhan Deyneli[SUP] 1 [/SUP], Faruk Alagol[SUP] 13 [/SUP], Refik Tanakol[SUP] 13 [/SUP], Mustafa Eroglu[SUP] 14 [/SUP], Ummu Mutlu[SUP] 15 [/SUP], Hulya Hacisahinogullari[SUP] 15 [/SUP], Ayse Kubat Uzum[SUP] 15 [/SUP], Canan Demir[SUP] 16 [/SUP], Gonul Koç[SUP] 17 [/SUP], Sevde Nur Fırat[SUP] 17 [/SUP], Tulay Omma[SUP] 18 [/SUP], Nurcan Ince[SUP] 19 [/SUP], Şefika Burcak Polat[SUP] 19 [/SUP], Oya Topaloglu[SUP] 19 [/SUP], Cevdet Aydın[SUP] 19 [/SUP], Bekir Cakır[SUP] 19 [/SUP], Cigdem Tura Bahadır[SUP] 20 [/SUP], Mehmet Guven[SUP] 21 [/SUP], Mehmet Sözen[SUP] 22 [/SUP], Alev Selek[SUP] 22 [/SUP], Zeynep Canturk[SUP] 22 [/SUP], Berrin Cetinarslan[SUP] 22 [/SUP], Mustafa Aydemir[SUP] 23 [/SUP], Isilay Taskaldiran[SUP] 24 [/SUP], Yusuf Bozkus[SUP] 24 [/SUP], Özlem Turhan Iyidir[SUP] 24 [/SUP], Filiz Eksi Haydardedeoglu[SUP] 25 [/SUP], Seda Erem Basmaz[SUP] 26 [/SUP], Mehmet Cagri Unal[SUP] 27 [/SUP], Tevfik Demir[SUP] 27 [/SUP], Ayten Oguz[SUP] 28 [/SUP], Ozlem Celik[SUP] 29 [/SUP], Merve Yilmaz[SUP] 30 [/SUP], Aykut Cimsir[SUP] 10 [/SUP], Serdar Kayihan[SUP] 10 [/SUP], Ziynet Alphan Uc[SUP] 31 [/SUP], Sakin Tekin[SUP] 32 [/SUP], Ömercan Topaloglu[SUP] 33 [/SUP], Basak Ozgen Saydam[SUP] 34 [/SUP], Yasemin Aydogan Unsal[SUP] 34 [/SUP], Ozge Ozer[SUP] 35 [/SUP], Goknur Yorulmaz[SUP] 35 [/SUP], Kader Ugur[SUP] 36 [/SUP], Sezin Dogan Cakir[SUP] 37 [/SUP], Mehmet Asik[SUP] 38 [/SUP], Mustafa Unubol[SUP] 39 [/SUP], Selin Genc[SUP] 40 [/SUP], Burak Andac[SUP] 41 [/SUP], Mine Okur[SUP] 41 [/SUP], Ozlem Dogan[SUP] 42 [/SUP], Ersen Karakiliç[SUP] 43 [/SUP], Gokcen Unal Kocabas[SUP] 44 [/SUP], Cem Onur Kirac[SUP] 45 [/SUP], Guven Baris Cansu[SUP] 46 [/SUP], Meliha Melin Uygur[SUP] 47 [/SUP], Zafer Pekkolay[SUP] 48 [/SUP], Sadettin Ozturk[SUP] 49 [/SUP], Askin Gungunes[SUP] 50 [/SUP], Eren Gurkan[SUP] 51 [/SUP], Lezzan Keskin[SUP] 52 [/SUP], Kenan Caglayan[SUP] 53 [/SUP], Yasemin Emur Gunay[SUP] 54 [/SUP], Eren İmre[SUP] 55 [/SUP], Selcuk Yusuf Sener[SUP] 56 [/SUP], Ahmet Toygar Kalkan[SUP] 57 [/SUP], Deniz Engin Gok[SUP] 58 [/SUP], Mustafa Sahin[SUP] 9 [/SUP]
Affiliations
- PMID: 37186260
- DOI: 10.1210/clinem/dgad235
Background/aim: The aims of the study are to compare characteristics of subacute thyroiditis (SAT) related to different aetiologies, and to identify predictors of recurrence of SAT and incident hypothyroidism.
Methods: This nationwide multicenter retrospective cohort study included 53 endocrinology centers in Turkey. The study participants were divided into either coronavirus disease-2019 (COVID-19)-related SAT (Cov-SAT), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related SAT (Vac-SAT), or control SAT (Cont-SAT).
Results: Of the 811 patients, 258 (31·8%) were included in the Vac-SAT group, 98 (12·1%) in the Cov-SAT group, and 455 (56·1%) in the Cont-SAT group. No difference was found between the groups with regard to laboratory and imaging findings. The aetiology of SAT was not an independent predictor of recurrence or hypothyroidism. In the entire cohort, steroid therapy requirement and younger age were statistically significant predictors for SAT recurrence. C-reactive protein (CRP) measured during SAT onset, female gender, absence of anti-thyroid peroxidase (TPO) positivity, and absence of steroid therapy were statistically significant predictors of incident (early) hypothyroidism, irrespective of SAT aetiology. On the other hand, probable predictors of established hypothyroidism differed from that of incident hypothyroidism.
Conclusion: Since there is no difference in terms of follow-up parameters and outcomes, COVID-19- and SARS-CoV-2- vaccine related SATs can be treated and followed up like classical SATs. The recurrence was determined by the younger age and steroid therapy requirement. Steroid therapy independently predict incident hypothyroidism that may sometimes be transient in overall SATs and is also associated with lower risk of established hypothyroidism.
Keywords: COVID-19; SARS-CoV-2 vaccine; subacute thyroiditis.