tetano
Editor, Senior Moderator
J Cell Physiol
. 2020 Sep 9.
doi: 10.1002/jcp.30041. Online ahead of print.
ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID-19
Seyed Ali Ziai[SUP] 1 [/SUP], Mitrasadat Rezaei[SUP] 2 [/SUP], Sajad Fakhri[SUP] 3 [/SUP], Ramin Pouriran[SUP] 1 [/SUP]
Affiliations
Abstract
COVID-19, a new disease caused by the 2019-novel coronavirus (SARS-CoV-2), has swept the world and challenged its culture, economy, and health infrastructure. Forced emergence to find an effective vaccine to immunize people has led scientists to design and examine vaccine candidates all over the world. Until a vaccine is developed, however, effective treatment is needed to combat this virus, which is resistant to all conventional antiviral drugs. Accordingly, more about the structure, entry mechanism, and pathogenesis of COVID-19 is required. Angiotensin-converting enzyme 2 (ACE2) is the gateway to SARS-CoV and SARS-CoV-2, so our knowledge of SARS-CoV-2 can help us to complete its mechanism of interaction with ACE2 and virus endocytosis, which can be interrupted by neutralizing small molecules or proteins. ACE2 also plays a crucial role in lung injury.
Keywords: ACE2; ARDS; COVID-19; SARS-CoV-2; angiotensin-converting enzyme 2; miRNA.
. 2020 Sep 9.
doi: 10.1002/jcp.30041. Online ahead of print.
ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID-19
Seyed Ali Ziai[SUP] 1 [/SUP], Mitrasadat Rezaei[SUP] 2 [/SUP], Sajad Fakhri[SUP] 3 [/SUP], Ramin Pouriran[SUP] 1 [/SUP]
Affiliations
- PMID: 32901940
- DOI: 10.1002/jcp.30041
Abstract
COVID-19, a new disease caused by the 2019-novel coronavirus (SARS-CoV-2), has swept the world and challenged its culture, economy, and health infrastructure. Forced emergence to find an effective vaccine to immunize people has led scientists to design and examine vaccine candidates all over the world. Until a vaccine is developed, however, effective treatment is needed to combat this virus, which is resistant to all conventional antiviral drugs. Accordingly, more about the structure, entry mechanism, and pathogenesis of COVID-19 is required. Angiotensin-converting enzyme 2 (ACE2) is the gateway to SARS-CoV and SARS-CoV-2, so our knowledge of SARS-CoV-2 can help us to complete its mechanism of interaction with ACE2 and virus endocytosis, which can be interrupted by neutralizing small molecules or proteins. ACE2 also plays a crucial role in lung injury.
Keywords: ACE2; ARDS; COVID-19; SARS-CoV-2; angiotensin-converting enzyme 2; miRNA.