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J Cell Biochem . Harnessing autophagy to fight SARS-CoV-2: An update in view of recent drug development efforts

tetano

tetano

Editor, Senior Moderator
J Cell Biochem


. 2021 Oct 20.
doi: 10.1002/jcb.30166. Online ahead of print.
Harnessing autophagy to fight SARS-CoV-2: An update in view of recent drug development efforts


Theo Rein[SUP] 1 [/SUP]



Affiliations

Abstract

Drug repurposing is an attractive option for identifying new treatment strategies, in particular in extraordinary situations of urgent need such as the current coronavirus disease 2019 (Covid-19) pandemic. Recently, the World Health Organization announced testing of three drugs as potential Covid-19 therapeutics that are known for their dampening effect on the immune system. Thus, the underlying concept of selecting these drugs is to temper the potentially life-threatening overshooting of the immune system reacting to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. This viewpoint discusses the possibility that the impact of these and other drugs on autophagy contributes to their therapeutic effect by hampering the SARS-CoV-2 life cycle.

Keywords: Covid-19; SARS-CoV2; autophagy; drug repurposing; pharmacology; virophagy.
 
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