tetano
Editor, Senior Moderator
J Cardiovasc Transl Res
. 2022 Jan 1.
doi: 10.1007/s12265-021-10147-3. Online ahead of print.
The Effects of ATIR Blocker on the Severity of COVID-19 in Hypertensive Inpatients and Virulence of SARS-CoV-2 in Hypertensive hACE2 Transgenic Mice
Xiaoliang Jiang[SUP] #[/SUP][SUP] 1 [/SUP], Huadong Li[SUP] #[/SUP][SUP] 2 [/SUP], Yong Liu[SUP] #[/SUP][SUP] 3 [/SUP], Linlin Bao[SUP] #[/SUP][SUP] 1 [/SUP], Lingjun Zhan[SUP] #[/SUP][SUP] 1 [/SUP], Hong Gao[SUP] 1 [/SUP], Wei Deng[SUP] 1 [/SUP], Jing Xue[SUP] 1 [/SUP], Jiangning Liu[SUP] 1 [/SUP], Xing Liu[SUP] 1 [/SUP], Junli Li[SUP] 1 [/SUP], Jie Wang[SUP] 1 [/SUP], Shuang Wu[SUP] 2 [/SUP], Mingzhe Yan[SUP] 2 [/SUP], Wei Luo[SUP] 4 [/SUP], Pedro A Jose[SUP] 5 [/SUP], Chuan Qin[SUP] 1 [/SUP], Xiuhong Yang[SUP] 6 [/SUP], Dingyu Zhang[SUP] 2 [/SUP], Zhiwei Yang[SUP] 7 [/SUP]
Affiliations
Abstract
Angiotensin-converting enzyme 2 (ACE2) is required for the cellular entry of the severe acute respiratory syndrome coronavirus 2. ACE2, via the Ang-(1-7)-Mas-R axis, is part of the antihypertensive and cardioprotective effects of the renin-angiotensin system. We studied hospitalized COVID-19 patients with hypertension and hypertensive human(h) ACE2 transgenic mice to determine the outcome of COVID-19 with or without AT1 receptor (AT1R) blocker treatment. The severity of the illness and the levels of serum cardiac biomarkers (CK, CK-BM, cTnI), as well as the inflammation markers (IL-1, IL-6, CRP), were lesser in hypertensive COVID-19 patients treated with AT1R blockers than those treated with other antihypertensive drugs. Hypertensive hACE2 transgenic mice, pretreated with AT1R blocker, had increased ACE2 expression and SARS-CoV-2 in the kidney and heart, 1 day post-infection. We conclude that those hypertensive patients treated with AT1R blocker may be at higher risk for SARS-CoV-2 infection. However, AT1R blockers had no effect on the severity of the illness but instead may have protected COVID-19 patients from heart injury, via the ACE2-angiotensin1-7-Mas receptor axis.
Keywords: AT1 receptor blocker; Angiotensin converting enzyme 2; Coronavirus disease 2019; Hypertension.
. 2022 Jan 1.
doi: 10.1007/s12265-021-10147-3. Online ahead of print.
The Effects of ATIR Blocker on the Severity of COVID-19 in Hypertensive Inpatients and Virulence of SARS-CoV-2 in Hypertensive hACE2 Transgenic Mice
Xiaoliang Jiang[SUP] #[/SUP][SUP] 1 [/SUP], Huadong Li[SUP] #[/SUP][SUP] 2 [/SUP], Yong Liu[SUP] #[/SUP][SUP] 3 [/SUP], Linlin Bao[SUP] #[/SUP][SUP] 1 [/SUP], Lingjun Zhan[SUP] #[/SUP][SUP] 1 [/SUP], Hong Gao[SUP] 1 [/SUP], Wei Deng[SUP] 1 [/SUP], Jing Xue[SUP] 1 [/SUP], Jiangning Liu[SUP] 1 [/SUP], Xing Liu[SUP] 1 [/SUP], Junli Li[SUP] 1 [/SUP], Jie Wang[SUP] 1 [/SUP], Shuang Wu[SUP] 2 [/SUP], Mingzhe Yan[SUP] 2 [/SUP], Wei Luo[SUP] 4 [/SUP], Pedro A Jose[SUP] 5 [/SUP], Chuan Qin[SUP] 1 [/SUP], Xiuhong Yang[SUP] 6 [/SUP], Dingyu Zhang[SUP] 2 [/SUP], Zhiwei Yang[SUP] 7 [/SUP]
Affiliations
- PMID: 34973134
- DOI: 10.1007/s12265-021-10147-3
Abstract
Angiotensin-converting enzyme 2 (ACE2) is required for the cellular entry of the severe acute respiratory syndrome coronavirus 2. ACE2, via the Ang-(1-7)-Mas-R axis, is part of the antihypertensive and cardioprotective effects of the renin-angiotensin system. We studied hospitalized COVID-19 patients with hypertension and hypertensive human(h) ACE2 transgenic mice to determine the outcome of COVID-19 with or without AT1 receptor (AT1R) blocker treatment. The severity of the illness and the levels of serum cardiac biomarkers (CK, CK-BM, cTnI), as well as the inflammation markers (IL-1, IL-6, CRP), were lesser in hypertensive COVID-19 patients treated with AT1R blockers than those treated with other antihypertensive drugs. Hypertensive hACE2 transgenic mice, pretreated with AT1R blocker, had increased ACE2 expression and SARS-CoV-2 in the kidney and heart, 1 day post-infection. We conclude that those hypertensive patients treated with AT1R blocker may be at higher risk for SARS-CoV-2 infection. However, AT1R blockers had no effect on the severity of the illness but instead may have protected COVID-19 patients from heart injury, via the ACE2-angiotensin1-7-Mas receptor axis.
Keywords: AT1 receptor blocker; Angiotensin converting enzyme 2; Coronavirus disease 2019; Hypertension.