tetano
Editor, Senior Moderator
J Cardiothorac Vasc Anesth
. 2021 Mar 27;S1053-0770(21)00277-9.
doi: 10.1053/j.jvca.2021.03.035. Online ahead of print.
Outcomes and Risk Factors for Cardiovascular Events in Hospitalized COVID-19 Patients
Qian Xu[SUP] 1 [/SUP], Harideep Samanapally[SUP] 2 [/SUP], Pavani Nathala[SUP] 2 [/SUP], Vidyulata Salunkhe[SUP] 2 [/SUP], Stephen Furmanek[SUP] 2 [/SUP], Meredith N Cahill[SUP] 3 [/SUP], Trevor McGuffin[SUP] 4 [/SUP], Tahboub Mohammad[SUP] 2 [/SUP], Bradford Marsili[SUP] 5 [/SUP], Jessica Petrey[SUP] 6 [/SUP], Ruth Carrico[SUP] 2 [/SUP], Julio Ramirez[SUP] 2 [/SUP], Ozan Akca[SUP] 5 [/SUP], Sean P Clifford[SUP] 5 [/SUP], Siddharth Pahwa[SUP] 7 [/SUP], Lynn Roser[SUP] 4 [/SUP], Maiying Kong[SUP] 1 [/SUP], Jiapeng Huang[SUP] 8 [/SUP], Center of Excellence for Research in Infectious Diseases (CERID) Coronavirus Study Group on behalf of the COVID-19 CardioVascular Research Group (COVID-CVRG)
Affiliations
Abstract
Objective: To analyze outcomes and risk factors of cardiovascular events in a metropolitan coronavirus disease 2019 (COVID-19) database, and to perform a subgroup analysis in African American populations to determine whether outcomes and risk factors are influenced by race.
Design: Retrospective cohort analysis from March 9, 2020 to June 20, 2020.
Setting: Population-based study in Louisville, KY, USA.
Participants: Seven hundred adult inpatients hospitalized with COVID-19.
Interventions: N/A.
Measurements and main results: This cohort consisted of 126 patients (18%) with cardiovascular events and 574 patients without cardiovascular events. Patients with cardiovascular events had a much higher mortality rate than those without cardiovascular events (45.2% v 8.7%, p < 0.001). There was no difference between African American and white patients regarding mortality (43.9% v 46.3%, p = 1) and length of stay for survivors (11 days v 9.5 days, p = 0.301). Multiple logistics regression analysis suggested that male, race, lower SaO2/F[SUB]I[/SUB]O2, higher serum potassium, lower serum albumin, and number of cardiovascular comorbidities were highly associated with the occurrence of cardiovascular events in COVID-19 patients. Lower serum albumin and neoplastic and/or immune-compromised diseases were highly associated with cardiovascular events for African American COVID-19 patients. SaO2/F[SUB]I[/SUB]O2 ratio and cardiovascular comorbidity count were significantly associated with cardiovascular events in white patients.
Conclusions: Cardiovascular events were prevalent and associated with worse outcomes in hospitalized patients with COVID-19. Outcomes of cardiovascular events in African American and white COVID-19 patients were similar after propensity score matching analysis. There were common and unique risk factors for cardiovascular events in African American COVID-19 patients when compared with white patients.
Keywords: COVID-19; SARS-CoV-2; cardiovascular; coronavirus; outcome; risk factors.
. 2021 Mar 27;S1053-0770(21)00277-9.
doi: 10.1053/j.jvca.2021.03.035. Online ahead of print.
Outcomes and Risk Factors for Cardiovascular Events in Hospitalized COVID-19 Patients
Qian Xu[SUP] 1 [/SUP], Harideep Samanapally[SUP] 2 [/SUP], Pavani Nathala[SUP] 2 [/SUP], Vidyulata Salunkhe[SUP] 2 [/SUP], Stephen Furmanek[SUP] 2 [/SUP], Meredith N Cahill[SUP] 3 [/SUP], Trevor McGuffin[SUP] 4 [/SUP], Tahboub Mohammad[SUP] 2 [/SUP], Bradford Marsili[SUP] 5 [/SUP], Jessica Petrey[SUP] 6 [/SUP], Ruth Carrico[SUP] 2 [/SUP], Julio Ramirez[SUP] 2 [/SUP], Ozan Akca[SUP] 5 [/SUP], Sean P Clifford[SUP] 5 [/SUP], Siddharth Pahwa[SUP] 7 [/SUP], Lynn Roser[SUP] 4 [/SUP], Maiying Kong[SUP] 1 [/SUP], Jiapeng Huang[SUP] 8 [/SUP], Center of Excellence for Research in Infectious Diseases (CERID) Coronavirus Study Group on behalf of the COVID-19 CardioVascular Research Group (COVID-CVRG)
Affiliations
- PMID: 33867235
- DOI: 10.1053/j.jvca.2021.03.035
Abstract
Objective: To analyze outcomes and risk factors of cardiovascular events in a metropolitan coronavirus disease 2019 (COVID-19) database, and to perform a subgroup analysis in African American populations to determine whether outcomes and risk factors are influenced by race.
Design: Retrospective cohort analysis from March 9, 2020 to June 20, 2020.
Setting: Population-based study in Louisville, KY, USA.
Participants: Seven hundred adult inpatients hospitalized with COVID-19.
Interventions: N/A.
Measurements and main results: This cohort consisted of 126 patients (18%) with cardiovascular events and 574 patients without cardiovascular events. Patients with cardiovascular events had a much higher mortality rate than those without cardiovascular events (45.2% v 8.7%, p < 0.001). There was no difference between African American and white patients regarding mortality (43.9% v 46.3%, p = 1) and length of stay for survivors (11 days v 9.5 days, p = 0.301). Multiple logistics regression analysis suggested that male, race, lower SaO2/F[SUB]I[/SUB]O2, higher serum potassium, lower serum albumin, and number of cardiovascular comorbidities were highly associated with the occurrence of cardiovascular events in COVID-19 patients. Lower serum albumin and neoplastic and/or immune-compromised diseases were highly associated with cardiovascular events for African American COVID-19 patients. SaO2/F[SUB]I[/SUB]O2 ratio and cardiovascular comorbidity count were significantly associated with cardiovascular events in white patients.
Conclusions: Cardiovascular events were prevalent and associated with worse outcomes in hospitalized patients with COVID-19. Outcomes of cardiovascular events in African American and white COVID-19 patients were similar after propensity score matching analysis. There were common and unique risk factors for cardiovascular events in African American COVID-19 patients when compared with white patients.
Keywords: COVID-19; SARS-CoV-2; cardiovascular; coronavirus; outcome; risk factors.