tetano
Editor, Senior Moderator
J Cardiol Cases
. 2022 Jul 4.
doi: 10.1016/j.jccase.2022.06.006. Online ahead of print.
An autopsy case report of fulminant myocarditis: Following mRNA COVID-19 vaccination
Naoki Hoshino[SUP] 1 [/SUP], Masanobu Yanase[SUP] 1 [/SUP], Taisuke Ichiyasu[SUP] 2 [/SUP], Kazuhiko Kuwahara[SUP] 2 [/SUP], Hideki Kawai[SUP] 1 [/SUP], Takashi Muramatsu[SUP] 1 [/SUP], Hideki Ishii[SUP] 3 4 [/SUP], Tetsuya Tsukamoto[SUP] 2 [/SUP], Shin-Ichiro Morimoto[SUP] 1 [/SUP], Hideo Izawa[SUP] 1 [/SUP]
Affiliations
Abstract
There have been few case reports on fatal outcomes in patients with acute myocarditis after mRNA coronavirus disease 2019 (COVID-19) vaccination. In most cases of myocarditis after mRNA COVID-19 vaccination, the myocarditis is mild, and the prognosis is good. Here we report an autopsy case of fulminant myocarditis following mRNA COVID-19 vaccination. Learning Objective The global distribution of the mRNA coronavirus disease 2019 vaccine requires consideration of appropriate treatment for postvaccination myocarditis. Eosinophil-mediated immunological injury to cardiomyocytes can be involved in the cause of fulminant inflammation from the pathological findings of postvaccination myocarditis.
Keywords: Autopsy; Coronavirus disease 2019; Eosinophilic myocarditis; Myocarditis; Vaccination; mRNA.
. 2022 Jul 4.
doi: 10.1016/j.jccase.2022.06.006. Online ahead of print.
An autopsy case report of fulminant myocarditis: Following mRNA COVID-19 vaccination
Naoki Hoshino[SUP] 1 [/SUP], Masanobu Yanase[SUP] 1 [/SUP], Taisuke Ichiyasu[SUP] 2 [/SUP], Kazuhiko Kuwahara[SUP] 2 [/SUP], Hideki Kawai[SUP] 1 [/SUP], Takashi Muramatsu[SUP] 1 [/SUP], Hideki Ishii[SUP] 3 4 [/SUP], Tetsuya Tsukamoto[SUP] 2 [/SUP], Shin-Ichiro Morimoto[SUP] 1 [/SUP], Hideo Izawa[SUP] 1 [/SUP]
Affiliations
- PMID: 35812802
- PMCID: PMC9250935
- DOI: 10.1016/j.jccase.2022.06.006
Abstract
There have been few case reports on fatal outcomes in patients with acute myocarditis after mRNA coronavirus disease 2019 (COVID-19) vaccination. In most cases of myocarditis after mRNA COVID-19 vaccination, the myocarditis is mild, and the prognosis is good. Here we report an autopsy case of fulminant myocarditis following mRNA COVID-19 vaccination. Learning Objective The global distribution of the mRNA coronavirus disease 2019 vaccine requires consideration of appropriate treatment for postvaccination myocarditis. Eosinophil-mediated immunological injury to cardiomyocytes can be involved in the cause of fulminant inflammation from the pathological findings of postvaccination myocarditis.
Keywords: Autopsy; Coronavirus disease 2019; Eosinophilic myocarditis; Myocarditis; Vaccination; mRNA.