tetano
Editor, Senior Moderator
J Bronchology Interv Pulmonol
. 2022 Jul 1;29(3):186-190.
doi: 10.1097/LBR.0000000000000807. Epub 2021 Sep 22.
Bronchoscopy in Critically Ill COVID-19 Patients: Findings, Microbiological Profile, and Coinfection
Pere Serra Mitjà[SUP] 1 2 3 [/SUP], Carmen Centeno[SUP] 1 2 3 [/SUP], Ignasi Garcia-Olivé[SUP] 1 2 3 [/SUP], Adrià Antuori[SUP] 4 [/SUP], Maria Casadellà[SUP] 5 [/SUP], Rachid Tazi[SUP] 1 2 3 [/SUP], Fernando Armestar[SUP] 6 7 [/SUP], Ester Fernández[SUP] 8 7 [/SUP], Felipe Andreo[SUP] 1 2 7 3 [/SUP], Antoni Rosell[SUP] 1 2 7 3 [/SUP]
Affiliations
Abstract
Background: Bronchoscopy is a widely use technique in critically ill patients. Nosocomial coinfections are a cause of morbidity and mortality in intensive care units.
Objectives: Our aim was to describe bronchoscopy findings and analyze microbiological profile and probably coinfection through bronchial aspirate (BA) samples in patients with coronavirus disease 2019 pneumonia requiring intensive care unit admission.
Methods: Retrospective observational study analyzing the BA samples collected from intubated patients with coronavirus disease 2019 in a referral Hospital (Spain).
Results: One hundred fifty-five consecutive BA samples were collected from 75 patients. Ninety (58%) were positive cultures for different microorganisms, 11 (7.1%) were polymicrobial, and 37 (23.7%) contained resistant microorganisms. There was a statistically significant association between increased days of orotracheal intubation and positive BA (18.9 vs. 10.9 d, P<0.01), polymicrobial infection (22.11 vs. 13.54, P<0.01) and isolation of resistant microorganisms (18.88 vs. 10.94, P<0.01). In 88% of the cases a new antibiotic or change in antibiotic treatment was made.
Conclusion: Bronchoscopy in critically ill patient was safe and could be useful to manage these patients and conduct the microbiological study, that seems to be higher and different than in nonepidemic periods. The longer the intubation period, the greater the probability of coinfection, isolation of resistant microorganisms and polymicrobial infection.
. 2022 Jul 1;29(3):186-190.
doi: 10.1097/LBR.0000000000000807. Epub 2021 Sep 22.
Bronchoscopy in Critically Ill COVID-19 Patients: Findings, Microbiological Profile, and Coinfection
Pere Serra Mitjà[SUP] 1 2 3 [/SUP], Carmen Centeno[SUP] 1 2 3 [/SUP], Ignasi Garcia-Olivé[SUP] 1 2 3 [/SUP], Adrià Antuori[SUP] 4 [/SUP], Maria Casadellà[SUP] 5 [/SUP], Rachid Tazi[SUP] 1 2 3 [/SUP], Fernando Armestar[SUP] 6 7 [/SUP], Ester Fernández[SUP] 8 7 [/SUP], Felipe Andreo[SUP] 1 2 7 3 [/SUP], Antoni Rosell[SUP] 1 2 7 3 [/SUP]
Affiliations
- PMID: 35730778
- DOI: 10.1097/LBR.0000000000000807
Abstract
Background: Bronchoscopy is a widely use technique in critically ill patients. Nosocomial coinfections are a cause of morbidity and mortality in intensive care units.
Objectives: Our aim was to describe bronchoscopy findings and analyze microbiological profile and probably coinfection through bronchial aspirate (BA) samples in patients with coronavirus disease 2019 pneumonia requiring intensive care unit admission.
Methods: Retrospective observational study analyzing the BA samples collected from intubated patients with coronavirus disease 2019 in a referral Hospital (Spain).
Results: One hundred fifty-five consecutive BA samples were collected from 75 patients. Ninety (58%) were positive cultures for different microorganisms, 11 (7.1%) were polymicrobial, and 37 (23.7%) contained resistant microorganisms. There was a statistically significant association between increased days of orotracheal intubation and positive BA (18.9 vs. 10.9 d, P<0.01), polymicrobial infection (22.11 vs. 13.54, P<0.01) and isolation of resistant microorganisms (18.88 vs. 10.94, P<0.01). In 88% of the cases a new antibiotic or change in antibiotic treatment was made.
Conclusion: Bronchoscopy in critically ill patient was safe and could be useful to manage these patients and conduct the microbiological study, that seems to be higher and different than in nonepidemic periods. The longer the intubation period, the greater the probability of coinfection, isolation of resistant microorganisms and polymicrobial infection.