tetano
Editor, Senior Moderator
J Biosaf Biosecur
. 2021 Dec 31.
doi: 10.1016/j.jobb.2021.12.001. Online ahead of print.
Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant
Yamin Sun[SUP] 1 2 [/SUP], Wenchao Lin[SUP] 2 [/SUP], Wei Dong[SUP] 2 [/SUP], Jianguo Xu[SUP] 1 3 [/SUP]
Affiliations
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly into new variants throughout the pandemic. The Omicron variant has more than 50 mutations when compared with the original wild-type strain and has been identified globally in numerous countries. In this report, we analyzed the mutational profiles of several variants, including the per-site mutation rate, to determine evolutionary relationships. The Omicron variant was found to have a unique mutation profile when compared with that of other SARS-CoV-2 variants, containing mutations that are rare in clinical samples. Moreover, the presence of five mouse-adapted mutation sites suggests that Omicron may have evolved in a mouse host. Mutations in the Omicron receptor-binding domain (RBD) region, in particular, have potential implications for the ongoing pandemic.
Keywords: Omicron variant; SARS-CoV-2; mouse-adapted mutation; reverse zoonosis.
. 2021 Dec 31.
doi: 10.1016/j.jobb.2021.12.001. Online ahead of print.
Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant
Yamin Sun[SUP] 1 2 [/SUP], Wenchao Lin[SUP] 2 [/SUP], Wei Dong[SUP] 2 [/SUP], Jianguo Xu[SUP] 1 3 [/SUP]
Affiliations
- PMID: 35005525
- PMCID: PMC8718870
- DOI: 10.1016/j.jobb.2021.12.001
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly into new variants throughout the pandemic. The Omicron variant has more than 50 mutations when compared with the original wild-type strain and has been identified globally in numerous countries. In this report, we analyzed the mutational profiles of several variants, including the per-site mutation rate, to determine evolutionary relationships. The Omicron variant was found to have a unique mutation profile when compared with that of other SARS-CoV-2 variants, containing mutations that are rare in clinical samples. Moreover, the presence of five mouse-adapted mutation sites suggests that Omicron may have evolved in a mouse host. Mutations in the Omicron receptor-binding domain (RBD) region, in particular, have potential implications for the ongoing pandemic.
Keywords: Omicron variant; SARS-CoV-2; mouse-adapted mutation; reverse zoonosis.