tetano
Editor, Senior Moderator
J Biol Chem. 2020 Apr 10;295(15):4780-4781. doi: 10.1074/jbc.H120.013397.
Halting coronavirus polymerase.
Kirchdoerfer RN[SUP]1[/SUP].
Author information
Abstract
The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.
? 2020 Kirchdoerfer.
PMID:32277065DOI:10.1074/jbc.H120.013397
Halting coronavirus polymerase.
Kirchdoerfer RN[SUP]1[/SUP].
Author information
Abstract
The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.
? 2020 Kirchdoerfer.
PMID:32277065DOI:10.1074/jbc.H120.013397