tetano
Editor, Senior Moderator
J Atheroscler Thromb
. 2020 Aug 29.
doi: 10.5551/jat.57950. Online ahead of print.
Ischemic Necrosis of Lower Extremity in COVID-19: A Case Report
Yunlu Liu[SUP] 1 [/SUP], Peng Chen[SUP] 1 [/SUP], Muradil Mutar[SUP] 1 2 [/SUP], Man ****[SUP] 3 [/SUP], Zengwu Shao[SUP] 1 [/SUP], Yanjiu Han[SUP] 1 [/SUP], Wei Tong[SUP] 1 [/SUP], Yong Liu[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an acute infectious disease that spreads mainly via the respiratory route. Elderly patients or those with underlying diseases are more seriously affected. We report a case of COVID-19 infection in a geriatric patient with arteriovenous thrombosis of the right lower limb. Despite persistent anticoagulant therapy, the patient's arterial thrombosis continued to progress and presented with ischemic necrosis of the lower extremity. After amputation in this case, the levels of D-dimer and inflammatory cytokine increased progressively, and he presented with acute myocardial infarction, which progressed rapidly to multisystem organ failure. However, whether coronavirus can directly cause the damage of the cardiovascular system and thrombosis needs further investigation.
Keywords: COVID-19; Coronavirus; SARS-CoV-2; Thrombosis; Wuhan.
. 2020 Aug 29.
doi: 10.5551/jat.57950. Online ahead of print.
Ischemic Necrosis of Lower Extremity in COVID-19: A Case Report
Yunlu Liu[SUP] 1 [/SUP], Peng Chen[SUP] 1 [/SUP], Muradil Mutar[SUP] 1 2 [/SUP], Man ****[SUP] 3 [/SUP], Zengwu Shao[SUP] 1 [/SUP], Yanjiu Han[SUP] 1 [/SUP], Wei Tong[SUP] 1 [/SUP], Yong Liu[SUP] 1 [/SUP]
Affiliations
- PMID: 32863298
- DOI: 10.5551/jat.57950
Abstract
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an acute infectious disease that spreads mainly via the respiratory route. Elderly patients or those with underlying diseases are more seriously affected. We report a case of COVID-19 infection in a geriatric patient with arteriovenous thrombosis of the right lower limb. Despite persistent anticoagulant therapy, the patient's arterial thrombosis continued to progress and presented with ischemic necrosis of the lower extremity. After amputation in this case, the levels of D-dimer and inflammatory cytokine increased progressively, and he presented with acute myocardial infarction, which progressed rapidly to multisystem organ failure. However, whether coronavirus can directly cause the damage of the cardiovascular system and thrombosis needs further investigation.
Keywords: COVID-19; Coronavirus; SARS-CoV-2; Thrombosis; Wuhan.