tetano
Editor, Senior Moderator
J Asthma Allergy
. 2022 Feb 22;15:257-264.
doi: 10.2147/JAA.S344934. eCollection 2022.
COVID-19 Course in Allergic Asthma Patients: A Spanish Cohort Analysis
Alicia Habernau Mena[SUP] #[/SUP][SUP] 1 [/SUP], Ismael García-Moguel[SUP] #[/SUP][SUP] 2 3 [/SUP], María Vazquez de la Torre Gaspar[SUP] 4 [/SUP], Victoria Mugica[SUP] 5 [/SUP], Maria Isabel Alvarado Izquierdo[SUP] 6 [/SUP], Maria Aranzazu Jimenez Blanco[SUP] 7 [/SUP], Mar Gandolfo-Cano[SUP] 8 [/SUP], Mar Jiménez Lara[SUP] 9 [/SUP], Ana Gonzalez Moreno[SUP] 10 [/SUP], Pilar Saura Foix[SUP] 11 [/SUP], Ana Navarro-Pulido[SUP] 12 [/SUP], Cristina Martin-Arriscado Arroba[SUP] 13 [/SUP], Julio Delgado Romero[SUP] 14 [/SUP], Javier Dominguez-Ortega[SUP] 15 [/SUP], Asthma Committee of SOCIEDAD ESPAÑOLA DE ALERGOLOGÍA E INMUNOLOGÍA CLÍNICA (SEAIC)
Affiliations
Abstract
Purpose: The acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had a high impact on patients with chronic diseases. In the literature, there are different perspectives on asthma as comorbidity or risk factor on COVID-19 severity.
Patients and methods: The aim of this retrospective study across 13 allergy departments in Spain was to determine the severity of COVID-19 in asthmatic adults followed in allergy departments and its relationship with atopy, clinical and demographic characteristics, phenotypes and laboratory data. In addition, lung function test and asthma control test (ACT) before and after COVID-19 were analyzed. Data was obtained from electronic medical records from March 2020 to April 2021.
Results: Two hundred one asthmatic patients were diagnosed with COVID-19 infection by validated detection test. About 30% of the patients were admitted for bilateral pneumonia. Advanced age, elevated D-dimer, lower numbers of lymphocytes and eosinophils, heart diseases and hypertension were associated with severe COVID-19. Allergic and mixed allergic/eosinophilic phenotype and their biomarkers (total IgE, aeroallergens sensitizations, allergic rhinitis, and blood eosinophilia) were related to fewer hospital admissions. Poor control and lower forced expiratory volume in the first second (FEV[SUB]1[/SUB]) were related to worse prognosis of COVID-19.
Conclusion: Asthmatic patients with allergic and eosinophilic phenotype have a better evolution of COVID-19 and lower risk of admissions. Older patients, cardiovascular comorbidities, AERD and eosinopenia are related to severity COVID-19.
Keywords: COVID-19; SARS-CoV-2; allergic asthma; asthma phenotype; eosinophils.
. 2022 Feb 22;15:257-264.
doi: 10.2147/JAA.S344934. eCollection 2022.
COVID-19 Course in Allergic Asthma Patients: A Spanish Cohort Analysis
Alicia Habernau Mena[SUP] #[/SUP][SUP] 1 [/SUP], Ismael García-Moguel[SUP] #[/SUP][SUP] 2 3 [/SUP], María Vazquez de la Torre Gaspar[SUP] 4 [/SUP], Victoria Mugica[SUP] 5 [/SUP], Maria Isabel Alvarado Izquierdo[SUP] 6 [/SUP], Maria Aranzazu Jimenez Blanco[SUP] 7 [/SUP], Mar Gandolfo-Cano[SUP] 8 [/SUP], Mar Jiménez Lara[SUP] 9 [/SUP], Ana Gonzalez Moreno[SUP] 10 [/SUP], Pilar Saura Foix[SUP] 11 [/SUP], Ana Navarro-Pulido[SUP] 12 [/SUP], Cristina Martin-Arriscado Arroba[SUP] 13 [/SUP], Julio Delgado Romero[SUP] 14 [/SUP], Javier Dominguez-Ortega[SUP] 15 [/SUP], Asthma Committee of SOCIEDAD ESPAÑOLA DE ALERGOLOGÍA E INMUNOLOGÍA CLÍNICA (SEAIC)
Affiliations
- PMID: 35228805
- PMCID: PMC8881918
- DOI: 10.2147/JAA.S344934
Abstract
Purpose: The acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had a high impact on patients with chronic diseases. In the literature, there are different perspectives on asthma as comorbidity or risk factor on COVID-19 severity.
Patients and methods: The aim of this retrospective study across 13 allergy departments in Spain was to determine the severity of COVID-19 in asthmatic adults followed in allergy departments and its relationship with atopy, clinical and demographic characteristics, phenotypes and laboratory data. In addition, lung function test and asthma control test (ACT) before and after COVID-19 were analyzed. Data was obtained from electronic medical records from March 2020 to April 2021.
Results: Two hundred one asthmatic patients were diagnosed with COVID-19 infection by validated detection test. About 30% of the patients were admitted for bilateral pneumonia. Advanced age, elevated D-dimer, lower numbers of lymphocytes and eosinophils, heart diseases and hypertension were associated with severe COVID-19. Allergic and mixed allergic/eosinophilic phenotype and their biomarkers (total IgE, aeroallergens sensitizations, allergic rhinitis, and blood eosinophilia) were related to fewer hospital admissions. Poor control and lower forced expiratory volume in the first second (FEV[SUB]1[/SUB]) were related to worse prognosis of COVID-19.
Conclusion: Asthmatic patients with allergic and eosinophilic phenotype have a better evolution of COVID-19 and lower risk of admissions. Older patients, cardiovascular comorbidities, AERD and eosinopenia are related to severity COVID-19.
Keywords: COVID-19; SARS-CoV-2; allergic asthma; asthma phenotype; eosinophils.