tetano
Editor, Senior Moderator
J Anesth
. 2023 Mar 17.
doi: 10.1007/s00540-023-03175-7. Online ahead of print.
Investigation of factors affecting COVID-19 pancreatic injury: a single-center, retrospective study
Satoshi Komatsu[SUP] 1 [/SUP], Tomoaki Yatabe[SUP] 2 [/SUP], Yoshitaka Hara[SUP] 1 [/SUP], Naohide Kuriyama[SUP] 1 [/SUP], Tomoyuki Nakamura[SUP] 1 [/SUP], Osamu Nishida[SUP] 3 [/SUP]
Affiliations
Abstract
Pancreatic injury is considered an organ-related complication in patients with coronavirus disease 2019 (COVID-19). However, it is unclear whether COVID-19 status affects pancreatic injury. This retrospective study aimed to determine whether COVID-19 affects the occurrence of pancreatic injuries. Consecutive patients diagnosed with sepsis admitted to the ICU between March 2020 and September 2021 were included. The primary endpoint was a pancreatic injury, which was defined as amylase or lipase levels > 3 times the upper limit of the normal range. Among the 177 patients included in the analysis, 40 (23%) were COVID-19 patients, and 54 (31%) had pancreatic injuries. Of these three patients, acute pancreatitis was diagnosed based on computed tomography. The pancreatic injury was significantly more common among COVID-19 patients (75 vs. 18%, p < 0.001). Multivariate analysis showed that COVID-19 and steroid use were independent risk factors for pancreatic injury (Odds Ratio (OR) 4.79 [95% confidence interval (CI) 1.48-15.5], p = 0.009; OR 4.02 [95% CI 1.42-11.4], p = 0.009). This study revealed that the proportion of pancreatic injury in septic patients with COVID-19 was significantly higher than in those without COVID-19. It may be difficult to diagnose pancreatitis based on amylase and lipase levels in COVID-19 patients.
Keywords: COVID-19; Hyperamylasemia; Pancreatic injury; Sepsis.
. 2023 Mar 17.
doi: 10.1007/s00540-023-03175-7. Online ahead of print.
Investigation of factors affecting COVID-19 pancreatic injury: a single-center, retrospective study
Satoshi Komatsu[SUP] 1 [/SUP], Tomoaki Yatabe[SUP] 2 [/SUP], Yoshitaka Hara[SUP] 1 [/SUP], Naohide Kuriyama[SUP] 1 [/SUP], Tomoyuki Nakamura[SUP] 1 [/SUP], Osamu Nishida[SUP] 3 [/SUP]
Affiliations
- PMID: 36930274
- DOI: 10.1007/s00540-023-03175-7
Abstract
Pancreatic injury is considered an organ-related complication in patients with coronavirus disease 2019 (COVID-19). However, it is unclear whether COVID-19 status affects pancreatic injury. This retrospective study aimed to determine whether COVID-19 affects the occurrence of pancreatic injuries. Consecutive patients diagnosed with sepsis admitted to the ICU between March 2020 and September 2021 were included. The primary endpoint was a pancreatic injury, which was defined as amylase or lipase levels > 3 times the upper limit of the normal range. Among the 177 patients included in the analysis, 40 (23%) were COVID-19 patients, and 54 (31%) had pancreatic injuries. Of these three patients, acute pancreatitis was diagnosed based on computed tomography. The pancreatic injury was significantly more common among COVID-19 patients (75 vs. 18%, p < 0.001). Multivariate analysis showed that COVID-19 and steroid use were independent risk factors for pancreatic injury (Odds Ratio (OR) 4.79 [95% confidence interval (CI) 1.48-15.5], p = 0.009; OR 4.02 [95% CI 1.42-11.4], p = 0.009). This study revealed that the proportion of pancreatic injury in septic patients with COVID-19 was significantly higher than in those without COVID-19. It may be difficult to diagnose pancreatitis based on amylase and lipase levels in COVID-19 patients.
Keywords: COVID-19; Hyperamylasemia; Pancreatic injury; Sepsis.