tetano
Editor, Senior Moderator
J Am Soc Nephrol. 2020 Apr 21. pii: ASN.2020030375. doi: 10.1681/ASN.2020030375. [Epub ahead of print]
Early Description of Coronavirus 2019 Disease in Kidney Transplant Recipients in New York.
Columbia University Kidney Transplant Program.
Collaborators (17)
Abstract
BACKGROUND:
The novel SARS-CoV-2 virus has caused a global pandemic of coronavirus disease 2019 (COVID-19). Although immunosuppressed individuals are thought to be at an increased risk of severe disease, little is known about their clinical presentation, disease course, or outcomes.
METHODS:
We report 15 kidney transplant recipients from the Columbia University kidney transplant program who required hospitalization for confirmed COVID-19, and describe their management, clinical course, and outcomes.
RESULTS:
Patients presented most often with a fever (87%) and/or cough (67%). Initial chest x-ray most commonly showed bilateral infiltrates, but 33% had no acute radiographic findings. Patients were managed with immunosuppression reduction and the addition of hydroxychloroquine and azithromycin. Although 27% of our patients needed mechanical ventilation, over half were discharged home by the end of follow-up.
CONCLUSIONS:
Kidney transplant recipients with COVID-19 have presentations that are similar to that of the general population. Our current treatment protocol appears to be associated with favorable outcomes, but longer follow-up of a larger cohort of patients is needed.
Copyright ? 2020 by the American Society of Nephrology.
KEYWORDS:
COVID-19; Epidemiology and outcomes; kidney transplantation; transplant outcomes
PMID:32317402DOI:10.1681/ASN.2020030375
Early Description of Coronavirus 2019 Disease in Kidney Transplant Recipients in New York.
Columbia University Kidney Transplant Program.
Collaborators (17)
Abstract
BACKGROUND:
The novel SARS-CoV-2 virus has caused a global pandemic of coronavirus disease 2019 (COVID-19). Although immunosuppressed individuals are thought to be at an increased risk of severe disease, little is known about their clinical presentation, disease course, or outcomes.
METHODS:
We report 15 kidney transplant recipients from the Columbia University kidney transplant program who required hospitalization for confirmed COVID-19, and describe their management, clinical course, and outcomes.
RESULTS:
Patients presented most often with a fever (87%) and/or cough (67%). Initial chest x-ray most commonly showed bilateral infiltrates, but 33% had no acute radiographic findings. Patients were managed with immunosuppression reduction and the addition of hydroxychloroquine and azithromycin. Although 27% of our patients needed mechanical ventilation, over half were discharged home by the end of follow-up.
CONCLUSIONS:
Kidney transplant recipients with COVID-19 have presentations that are similar to that of the general population. Our current treatment protocol appears to be associated with favorable outcomes, but longer follow-up of a larger cohort of patients is needed.
Copyright ? 2020 by the American Society of Nephrology.
KEYWORDS:
COVID-19; Epidemiology and outcomes; kidney transplantation; transplant outcomes
PMID:32317402DOI:10.1681/ASN.2020030375