tetano
Editor, Senior Moderator
J Am Heart Assoc
. 2020 Aug 14;e016796.
doi: 10.1161/JAHA.120.016796. Online ahead of print.
Clinical Characteristics and Prognosis of 244 Cardiovascular Patients Suffering from Coronavirus Disease in Wuhan, China
Yudong Peng[SUP] 1 [/SUP], Kai Meng[SUP] 1 [/SUP], Meian He[SUP] 2 [/SUP], Ruirui Zhu[SUP] 1 [/SUP], Hongquan Guan[SUP] 1 [/SUP], Zihan Ke[SUP] 1 [/SUP], Liang Leng[SUP] 1 [/SUP], Xiang Wang[SUP] 1 [/SUP], Bende Liu[SUP] 3 [/SUP], Caiying Hu[SUP] 4 [/SUP], Qingwei Ji[SUP] 5 [/SUP], Mulatibieke Keerman[SUP] 2 [/SUP], Longxian Cheng[SUP] 1 [/SUP], Tangchun Wu[SUP] 2 [/SUP], Kai Huang[SUP] 1 [/SUP], Qiutang Zeng[SUP] 1 [/SUP]
Affiliations
Abstract
BackgroundThe coronavirus disease (COVID-19) has developed into a global outbreak. Cardiovascular disease (CVD) patients with COVID-19 have different clinical characteristics and prognostic outcomes. This study aimed to summarize the clinical characteristics and laboratory indicators of COVID-19 patients with CVD, especially the critically ill patients. Methods and Results This study included 244 patients diagnosed with COVID-19 and CVD (hypertension, coronary heart disease, or heart failure). The patients were categorized into critical (n=36) and non-critical (n=208) groups according to the interim guidance of China's National Health Commission. Clinical, laboratory, and outcome data were collected from the patients' medical records and compared between the two groups. The average body mass index (BMI) of patients was significantly higher in the critical group than in the non-critical group. Neutrophil/lymphocyte ratio, and C-reactive protein, procalcitonin, and fibrinogen, and D-dimer levels at admission were significantly increased in the critical group. The all-cause mortality rate among cases of COVID-19 combined with CVD was 19.26%; the proportion of coronary heart disease and heart failure was significantly higher in deceased patients than in recovered patients. High BMI, previous history of coronary heart disease, lactic acid accumulation, and a decrease in the partial pressure of oxygen were associated with death. Conclusions All-cause mortality in COVID-19 patients with CVD in hospitals is high. The high neutrophil/lymphocyte ratio may be a predictor of critical patients. Overweight/obesity combined with coronary heart disease, severe hypoxia, and lactic acid accumulation resulting from respiratory failure are related to poor outcomes.
Keywords: COVID‐19; SARS‐CoV‐2; cardiovascular disease; coronavirus disease; respiratory failure; severe acute respiratory syndrome coronavirus 2.
. 2020 Aug 14;e016796.
doi: 10.1161/JAHA.120.016796. Online ahead of print.
Clinical Characteristics and Prognosis of 244 Cardiovascular Patients Suffering from Coronavirus Disease in Wuhan, China
Yudong Peng[SUP] 1 [/SUP], Kai Meng[SUP] 1 [/SUP], Meian He[SUP] 2 [/SUP], Ruirui Zhu[SUP] 1 [/SUP], Hongquan Guan[SUP] 1 [/SUP], Zihan Ke[SUP] 1 [/SUP], Liang Leng[SUP] 1 [/SUP], Xiang Wang[SUP] 1 [/SUP], Bende Liu[SUP] 3 [/SUP], Caiying Hu[SUP] 4 [/SUP], Qingwei Ji[SUP] 5 [/SUP], Mulatibieke Keerman[SUP] 2 [/SUP], Longxian Cheng[SUP] 1 [/SUP], Tangchun Wu[SUP] 2 [/SUP], Kai Huang[SUP] 1 [/SUP], Qiutang Zeng[SUP] 1 [/SUP]
Affiliations
- PMID: 32794415
- DOI: 10.1161/JAHA.120.016796
Abstract
BackgroundThe coronavirus disease (COVID-19) has developed into a global outbreak. Cardiovascular disease (CVD) patients with COVID-19 have different clinical characteristics and prognostic outcomes. This study aimed to summarize the clinical characteristics and laboratory indicators of COVID-19 patients with CVD, especially the critically ill patients. Methods and Results This study included 244 patients diagnosed with COVID-19 and CVD (hypertension, coronary heart disease, or heart failure). The patients were categorized into critical (n=36) and non-critical (n=208) groups according to the interim guidance of China's National Health Commission. Clinical, laboratory, and outcome data were collected from the patients' medical records and compared between the two groups. The average body mass index (BMI) of patients was significantly higher in the critical group than in the non-critical group. Neutrophil/lymphocyte ratio, and C-reactive protein, procalcitonin, and fibrinogen, and D-dimer levels at admission were significantly increased in the critical group. The all-cause mortality rate among cases of COVID-19 combined with CVD was 19.26%; the proportion of coronary heart disease and heart failure was significantly higher in deceased patients than in recovered patients. High BMI, previous history of coronary heart disease, lactic acid accumulation, and a decrease in the partial pressure of oxygen were associated with death. Conclusions All-cause mortality in COVID-19 patients with CVD in hospitals is high. The high neutrophil/lymphocyte ratio may be a predictor of critical patients. Overweight/obesity combined with coronary heart disease, severe hypoxia, and lactic acid accumulation resulting from respiratory failure are related to poor outcomes.
Keywords: COVID‐19; SARS‐CoV‐2; cardiovascular disease; coronavirus disease; respiratory failure; severe acute respiratory syndrome coronavirus 2.