tetano
Editor, Senior Moderator
J Alzheimers Dis
. 2021 Oct 20.
doi: 10.3233/JAD-215161. Online ahead of print.
COVID-19 Case Fatality and Alzheimer's Disease
Qiang Zhang[SUP] 1 [/SUP], Jordan L Schultz[SUP] 1 2 [/SUP], Georgina M Aldridge[SUP] 1 [/SUP], Jacob E Simmering[SUP] 3 [/SUP], Youngcho Kim[SUP] 1 [/SUP], Amy C Ogilvie[SUP] 2 4 [/SUP], Nandakumar S Narayanan[SUP] 1 [/SUP]
Affiliations
Abstract
Previous studies have identified dementia as a risk factor for death from coronavirus disease 2019 (COVID-19). However, it is unclear whether Alzheimer's disease (AD) is an independent risk factor for COVID-19 case fatality rate. In a retrospective cohort study, we identified 387,841 COVID-19 patients through TriNetX. After adjusting for demographics and comorbidities, we found that AD patients had higher odds of dying from COVID-19 compared to patients without AD (Odds Ratio: 1.20, 95%confidence interval: 1.09-1.32, p < 0.001). Interestingly, we did not observe increased mortality from COVID-19 among patients with vascular dementia. These data are relevant to the evolving COVID-19 pandemic.
Keywords: Alzheimer’s disease; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); case fatality; dementia with Lewy bodies; frontotemporal dementia; vascular dementia.
. 2021 Oct 20.
doi: 10.3233/JAD-215161. Online ahead of print.
COVID-19 Case Fatality and Alzheimer's Disease
Qiang Zhang[SUP] 1 [/SUP], Jordan L Schultz[SUP] 1 2 [/SUP], Georgina M Aldridge[SUP] 1 [/SUP], Jacob E Simmering[SUP] 3 [/SUP], Youngcho Kim[SUP] 1 [/SUP], Amy C Ogilvie[SUP] 2 4 [/SUP], Nandakumar S Narayanan[SUP] 1 [/SUP]
Affiliations
- PMID: 34690147
- DOI: 10.3233/JAD-215161
Abstract
Previous studies have identified dementia as a risk factor for death from coronavirus disease 2019 (COVID-19). However, it is unclear whether Alzheimer's disease (AD) is an independent risk factor for COVID-19 case fatality rate. In a retrospective cohort study, we identified 387,841 COVID-19 patients through TriNetX. After adjusting for demographics and comorbidities, we found that AD patients had higher odds of dying from COVID-19 compared to patients without AD (Odds Ratio: 1.20, 95%confidence interval: 1.09-1.32, p < 0.001). Interestingly, we did not observe increased mortality from COVID-19 among patients with vascular dementia. These data are relevant to the evolving COVID-19 pandemic.
Keywords: Alzheimer’s disease; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); case fatality; dementia with Lewy bodies; frontotemporal dementia; vascular dementia.