tetano
Editor, Senior Moderator
J Allergy Clin Immunol Pract
. 2022 Dec 22;S2213-2198(22)01312-5.
doi: 10.1016/j.jaip.2022.12.003. Online ahead of print.
Post-Acute COVID-19 Respiratory Symptoms in Patients with Asthma: An Electronic Health Records-based Study
Liqin Wang[SUP] 1 [/SUP], Dinah Foer[SUP] 2 [/SUP], Yuqing Zhang[SUP] 3 [/SUP], Elizabeth W Karlson[SUP] 4 [/SUP], David W Bates[SUP] 5 [/SUP], Li Zhou[SUP] 6 [/SUP]
Affiliations
Abstract
Background: Post-viral respiratory symptoms are common among patients with asthma. Respiratory symptoms post-acute COVID-19 are widely reported in the general population but large-scale studies identifying symptom risk for patients with asthma are lacking.
Objective: To identify and compare risk for post-acute COVID-19 respiratory symptoms in patients with and without asthma.
Methods: This retrospective, observational cohort study included COVID-19 positive patients between March 4, 2020 and January 20, 2021 with up to 180 days of healthcare follow-up in a healthcare system in the Northeastern United States. Respiratory symptoms recorded in clinical notes from days 28-180 post-COVID-19 diagnosis were extracted using natural language processing. Cohorts were stratified by hospitalization status during the acute COVID-19 period. Univariable and multivariable analyses were used to compare symptoms among patients with and without asthma adjusting for demographic and clinical confounders.
Results: Among 31,084 eligible COVID-19 patients, 2,863 (9.2%) had hospitalization during acute-COVID-19 period; 4,049 (13.0%) had a history of asthma, accounting for 13.8% of hospitalized and 12.9% of non-hospitalized patients. In the post-acute COVID-19 period, patients with asthma had significantly higher risk of shortness of breath, cough, bronchospasm and wheezing than patients without an asthma history. Incident respiratory symptoms of bronchospasm and wheezing were also higher in patients with asthma. Patients with asthma who had not been hospitalized during acute COVID-19, had additionally higher risk of cough, abnormal breathing, sputum changes, and a wider range of incident respiratory symptoms.
Conclusion: Patients with asthma may have an underrecognized burden of respiratory symptoms post-COVID-19 warranting increased awareness and monitoring in this population.
Keywords: SARS-CoV-2; coronavirus; electronic health records; natural language processing; post-viral.
. 2022 Dec 22;S2213-2198(22)01312-5.
doi: 10.1016/j.jaip.2022.12.003. Online ahead of print.
Post-Acute COVID-19 Respiratory Symptoms in Patients with Asthma: An Electronic Health Records-based Study
Liqin Wang[SUP] 1 [/SUP], Dinah Foer[SUP] 2 [/SUP], Yuqing Zhang[SUP] 3 [/SUP], Elizabeth W Karlson[SUP] 4 [/SUP], David W Bates[SUP] 5 [/SUP], Li Zhou[SUP] 6 [/SUP]
Affiliations
- PMID: 36566779
- DOI: 10.1016/j.jaip.2022.12.003
Abstract
Background: Post-viral respiratory symptoms are common among patients with asthma. Respiratory symptoms post-acute COVID-19 are widely reported in the general population but large-scale studies identifying symptom risk for patients with asthma are lacking.
Objective: To identify and compare risk for post-acute COVID-19 respiratory symptoms in patients with and without asthma.
Methods: This retrospective, observational cohort study included COVID-19 positive patients between March 4, 2020 and January 20, 2021 with up to 180 days of healthcare follow-up in a healthcare system in the Northeastern United States. Respiratory symptoms recorded in clinical notes from days 28-180 post-COVID-19 diagnosis were extracted using natural language processing. Cohorts were stratified by hospitalization status during the acute COVID-19 period. Univariable and multivariable analyses were used to compare symptoms among patients with and without asthma adjusting for demographic and clinical confounders.
Results: Among 31,084 eligible COVID-19 patients, 2,863 (9.2%) had hospitalization during acute-COVID-19 period; 4,049 (13.0%) had a history of asthma, accounting for 13.8% of hospitalized and 12.9% of non-hospitalized patients. In the post-acute COVID-19 period, patients with asthma had significantly higher risk of shortness of breath, cough, bronchospasm and wheezing than patients without an asthma history. Incident respiratory symptoms of bronchospasm and wheezing were also higher in patients with asthma. Patients with asthma who had not been hospitalized during acute COVID-19, had additionally higher risk of cough, abnormal breathing, sputum changes, and a wider range of incident respiratory symptoms.
Conclusion: Patients with asthma may have an underrecognized burden of respiratory symptoms post-COVID-19 warranting increased awareness and monitoring in this population.
Keywords: SARS-CoV-2; coronavirus; electronic health records; natural language processing; post-viral.