tetano
Editor, Senior Moderator
J Affect Disord
. 2020 Aug 20;277:337-340.
doi: 10.1016/j.jad.2020.08.031. Online ahead of print.
First report of manic-like symptoms in a COVID-19 patient with no previous history of a psychiatric disorder
Shaojia Lu[SUP] 1 [/SUP], Ning Wei[SUP] 1 [/SUP], Jiajun Jiang[SUP] 1 [/SUP], Lingling Wu[SUP] 1 [/SUP], Jifang Sheng[SUP] 2 [/SUP], Jianying Zhou[SUP] 3 [/SUP], Qiang Fang[SUP] 4 [/SUP], Yu Chen[SUP] 5 [/SUP], Shufa Zheng[SUP] 5 [/SUP], Feng Chen[SUP] 6 [/SUP], Tingbo Liang[SUP] 7 [/SUP], Shaohua Hu[SUP] 8 [/SUP]
Affiliations
Abstract
Background: In December 2019, the novel coronavirus (SARS-CoV-2) infection was first reported in Wuhan city, central China, which has spread rapidly. The common clinical features of patients with SARS-CoV-2 infection included fever, fatigue, and damage to the respiratory or digestive system. However, it is still unclear whether SARS-CoV-2 infection could cause damage to the central nervous system (CNS) inducing psychiatric symptoms.
Case report: Herein, we present the first case of SARS-CoV-2 infection with manic-like symptoms and describe the diagnosis, clinical course, and treatment of the case, focusing on the identifications of SARS-CoV-2 in the specimen of cerebrospinal fluid (CSF). The patient developed manic-like symptoms when his vital signs recovered on illness day 17. After manic-like attack, the detection of SARS-CoV-2 specific IgG antibody in CSF was positive, while the reverse transcriptase-polymerase chain reaction (RT-PCR) on CSF for the SARS-CoV-2 was negative. The patient received Olanzapine for treatment and his mood problems concurrently improved as indicated by scores of Young Manic Rating Scale (YMRS).
Limitation: This is a single case report only, and the RT-PCR test for SARS-CoV-2 in CSF was not performed simultaneously when SARS-CoV-2 was positive in samples of sputum and stool.
Conclusion: This first case of COVID-19 patient with manic-like symptoms highlights the importance of evaluation of mental health status and may contribute to our understanding of potential risk of CNS impairments by SARS-CoV-2 infection.
Keywords: Cerebrospinal fluid; IgG; Manic-like symptoms; SARS-CoV-2.
. 2020 Aug 20;277:337-340.
doi: 10.1016/j.jad.2020.08.031. Online ahead of print.
First report of manic-like symptoms in a COVID-19 patient with no previous history of a psychiatric disorder
Shaojia Lu[SUP] 1 [/SUP], Ning Wei[SUP] 1 [/SUP], Jiajun Jiang[SUP] 1 [/SUP], Lingling Wu[SUP] 1 [/SUP], Jifang Sheng[SUP] 2 [/SUP], Jianying Zhou[SUP] 3 [/SUP], Qiang Fang[SUP] 4 [/SUP], Yu Chen[SUP] 5 [/SUP], Shufa Zheng[SUP] 5 [/SUP], Feng Chen[SUP] 6 [/SUP], Tingbo Liang[SUP] 7 [/SUP], Shaohua Hu[SUP] 8 [/SUP]
Affiliations
- PMID: 32858315
- DOI: 10.1016/j.jad.2020.08.031
Abstract
Background: In December 2019, the novel coronavirus (SARS-CoV-2) infection was first reported in Wuhan city, central China, which has spread rapidly. The common clinical features of patients with SARS-CoV-2 infection included fever, fatigue, and damage to the respiratory or digestive system. However, it is still unclear whether SARS-CoV-2 infection could cause damage to the central nervous system (CNS) inducing psychiatric symptoms.
Case report: Herein, we present the first case of SARS-CoV-2 infection with manic-like symptoms and describe the diagnosis, clinical course, and treatment of the case, focusing on the identifications of SARS-CoV-2 in the specimen of cerebrospinal fluid (CSF). The patient developed manic-like symptoms when his vital signs recovered on illness day 17. After manic-like attack, the detection of SARS-CoV-2 specific IgG antibody in CSF was positive, while the reverse transcriptase-polymerase chain reaction (RT-PCR) on CSF for the SARS-CoV-2 was negative. The patient received Olanzapine for treatment and his mood problems concurrently improved as indicated by scores of Young Manic Rating Scale (YMRS).
Limitation: This is a single case report only, and the RT-PCR test for SARS-CoV-2 in CSF was not performed simultaneously when SARS-CoV-2 was positive in samples of sputum and stool.
Conclusion: This first case of COVID-19 patient with manic-like symptoms highlights the importance of evaluation of mental health status and may contribute to our understanding of potential risk of CNS impairments by SARS-CoV-2 infection.
Keywords: Cerebrospinal fluid; IgG; Manic-like symptoms; SARS-CoV-2.