tetano
Editor, Senior Moderator
IUBMB Life
. 2020 Aug 8.
doi: 10.1002/iub.2356. Online ahead of print.
Bacterial co-infections with SARS-CoV-2
Rasoul Mirzaei[SUP] 1 2 [/SUP], Pedram Goodarzi[SUP] 3 [/SUP], Muhammad Asadi[SUP] 4 [/SUP], Ayda Soltani[SUP] 5 [/SUP], Hussain Ali Abraham Aljanabi[SUP] 4 6 [/SUP], Ali Salimi Jeda[SUP] 7 [/SUP], Shirin Dashtbin[SUP] 8 [/SUP], Saba Jalalifar[SUP] 8 [/SUP], Rokhsareh Mohammadzadeh[SUP] 8 [/SUP], Ali Teimoori[SUP] 9 [/SUP], Kamran Tari[SUP] 2 10 [/SUP], Mehdi Salari[SUP] 2 10 [/SUP], Sima Ghiasvand[SUP] 1 [/SUP], Sima Kazemi[SUP] 1 [/SUP], Rasoul Yousefimashouf[SUP] 1 [/SUP], Hossein Keyvani[SUP] 7 [/SUP], Sajad Karampoor[SUP] 7 [/SUP]
Affiliations
Abstract
The pandemic coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has affected millions of people worldwide. To date, there are no proven effective therapies for this virus. Efforts made to develop antiviral strategies for the treatment of COVID-19 are underway. Respiratory viral infections, such as influenza, predispose patients to co-infections and these lead to increased disease severity and mortality. Numerous types of antibiotics such as azithromycin have been employed for the prevention and treatment of bacterial co-infection and secondary bacterial infections in patients with a viral respiratory infection (e.g., SARS-CoV-2). Although antibiotics do not directly affect SARS-CoV-2, viral respiratory infections often result in bacterial pneumonia. It is possible that some patients die from bacterial co-infection rather than virus itself. To date, a considerable number of bacterial strains have been resistant to various antibiotics such as azithromycin, and the overuse could render those or other antibiotics even less effective. Therefore, bacterial co-infection and secondary bacterial infection are considered critical risk factors for the severity and mortality rates of COVID-19. Also, the antibiotic-resistant as a result of overusing must be considered. In this review, we will summarize the bacterial co-infection and secondary bacterial infection in some featured respiratory viral infections, especially COVID-19.
Keywords: COVID-19; SARS-CoV-2; antibiotic; bacterial co-infection; viral infection.
. 2020 Aug 8.
doi: 10.1002/iub.2356. Online ahead of print.
Bacterial co-infections with SARS-CoV-2
Rasoul Mirzaei[SUP] 1 2 [/SUP], Pedram Goodarzi[SUP] 3 [/SUP], Muhammad Asadi[SUP] 4 [/SUP], Ayda Soltani[SUP] 5 [/SUP], Hussain Ali Abraham Aljanabi[SUP] 4 6 [/SUP], Ali Salimi Jeda[SUP] 7 [/SUP], Shirin Dashtbin[SUP] 8 [/SUP], Saba Jalalifar[SUP] 8 [/SUP], Rokhsareh Mohammadzadeh[SUP] 8 [/SUP], Ali Teimoori[SUP] 9 [/SUP], Kamran Tari[SUP] 2 10 [/SUP], Mehdi Salari[SUP] 2 10 [/SUP], Sima Ghiasvand[SUP] 1 [/SUP], Sima Kazemi[SUP] 1 [/SUP], Rasoul Yousefimashouf[SUP] 1 [/SUP], Hossein Keyvani[SUP] 7 [/SUP], Sajad Karampoor[SUP] 7 [/SUP]
Affiliations
- PMID: 32770825
- DOI: 10.1002/iub.2356
Abstract
The pandemic coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has affected millions of people worldwide. To date, there are no proven effective therapies for this virus. Efforts made to develop antiviral strategies for the treatment of COVID-19 are underway. Respiratory viral infections, such as influenza, predispose patients to co-infections and these lead to increased disease severity and mortality. Numerous types of antibiotics such as azithromycin have been employed for the prevention and treatment of bacterial co-infection and secondary bacterial infections in patients with a viral respiratory infection (e.g., SARS-CoV-2). Although antibiotics do not directly affect SARS-CoV-2, viral respiratory infections often result in bacterial pneumonia. It is possible that some patients die from bacterial co-infection rather than virus itself. To date, a considerable number of bacterial strains have been resistant to various antibiotics such as azithromycin, and the overuse could render those or other antibiotics even less effective. Therefore, bacterial co-infection and secondary bacterial infection are considered critical risk factors for the severity and mortality rates of COVID-19. Also, the antibiotic-resistant as a result of overusing must be considered. In this review, we will summarize the bacterial co-infection and secondary bacterial infection in some featured respiratory viral infections, especially COVID-19.
Keywords: COVID-19; SARS-CoV-2; antibiotic; bacterial co-infection; viral infection.