tetano
Editor, Senior Moderator
Epidemiol Infect. 2013 Jun 26:1-8. [Epub ahead of print]
Isolation and genetic characterization of naturally NS-truncated H3N8 equine influenza virus in South Korea.
Na W, Kang B, Kim HI, Hong M, Park SJ, Jeoung HY, An DJ, Moon H, Kim JK, Song D.
Source
Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.
Abstract
SUMMARY Equine influenza virus (EIV) causes a highly contagious respiratory disease in equids, with confirmed outbreaks in Europe, America, North Africa, and Asia. Although China, Mongolia, and Japan have reported equine influenza outbreaks, Korea has not. Since 2011, we have conducted a routine surveillance programme to detect EIV at domestic stud farms, and isolated H3N8 EIV from horses showing respiratory disease symptoms. Here, we characterized the genetic and biological properties of this novel Korean H3N8 EIV isolate. This H3N8 EIV isolate belongs to the Florida sublineage clade 1 of the American H3N8 EIV lineage, and surprisingly, possessed a non-structural protein (NS) gene segment, where 23 bases of the NS1-encoding region were naturally truncated. Our preliminary biological data indicated that this truncation did not affect virus replication; its effect on biological and immunological properties of the virus will require further study.
PMID:
23800580
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23800580
Isolation and genetic characterization of naturally NS-truncated H3N8 equine influenza virus in South Korea.
Na W, Kang B, Kim HI, Hong M, Park SJ, Jeoung HY, An DJ, Moon H, Kim JK, Song D.
Source
Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.
Abstract
SUMMARY Equine influenza virus (EIV) causes a highly contagious respiratory disease in equids, with confirmed outbreaks in Europe, America, North Africa, and Asia. Although China, Mongolia, and Japan have reported equine influenza outbreaks, Korea has not. Since 2011, we have conducted a routine surveillance programme to detect EIV at domestic stud farms, and isolated H3N8 EIV from horses showing respiratory disease symptoms. Here, we characterized the genetic and biological properties of this novel Korean H3N8 EIV isolate. This H3N8 EIV isolate belongs to the Florida sublineage clade 1 of the American H3N8 EIV lineage, and surprisingly, possessed a non-structural protein (NS) gene segment, where 23 bases of the NS1-encoding region were naturally truncated. Our preliminary biological data indicated that this truncation did not affect virus replication; its effect on biological and immunological properties of the virus will require further study.
PMID:
23800580
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23800580