tetano
Editor, Senior Moderator
iScience
. 2021 Sep 25;103172.
doi: 10.1016/j.isci.2021.103172. Online ahead of print.
The nasal symbiont Staphylococcus species restricts the transcription of SARS-CoV-2 entry factors in human nasal epithelium
Jeong Yeon Ji[SUP] 1 [/SUP], Ara Jo[SUP] 2 [/SUP], Jina Won[SUP] 2 [/SUP], Chan Hee Gil[SUP] 2 [/SUP], Haeun Shin[SUP] 2 [/SUP], Sujin Kim[SUP] 2 [/SUP], Yung Jin Jeon[SUP] 3 [/SUP], Hyun Jik Kim[SUP] 2 1 [/SUP]
Affiliations
Abstract
Emerging evidence indicates that severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is transmitted through the human nasal mucosa via the principal entry factors angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2), which are highly expressed in the nasal epithelium. Therefore, the biologics targeting host entry factors on human nasal mucosa will be necessary for complete control of SARS-CoV-2. Our data reveal that ACE2 was more abundant in human nasal mucosa than lung tissue. Both ACE2 and TMPRSS2 transcriptions were significantly decreased in nasal epithelium in response to S. epidermidis and were relatively lower in human nasal mucus with large number of S. epidermidis. ACE2 transcription was also reduced in nasal epithelium in response to nasal symbiont S. aureus. This study propose that Staphylococcus species nasal commensals might potentially restrict SARS-CoV-2 entry to the nasal epithelium via down regulation of cellular receptors coupled with reduction of principal host protease.
Keywords: ACE2; COVID-19; SARS-CoV-2; Staphylococcus aureus; Staphylococcus epidermidis; TMPRSS2.
. 2021 Sep 25;103172.
doi: 10.1016/j.isci.2021.103172. Online ahead of print.
The nasal symbiont Staphylococcus species restricts the transcription of SARS-CoV-2 entry factors in human nasal epithelium
Jeong Yeon Ji[SUP] 1 [/SUP], Ara Jo[SUP] 2 [/SUP], Jina Won[SUP] 2 [/SUP], Chan Hee Gil[SUP] 2 [/SUP], Haeun Shin[SUP] 2 [/SUP], Sujin Kim[SUP] 2 [/SUP], Yung Jin Jeon[SUP] 3 [/SUP], Hyun Jik Kim[SUP] 2 1 [/SUP]
Affiliations
- PMID: 34604720
- PMCID: PMC8464034
- DOI: 10.1016/j.isci.2021.103172
Abstract
Emerging evidence indicates that severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is transmitted through the human nasal mucosa via the principal entry factors angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2), which are highly expressed in the nasal epithelium. Therefore, the biologics targeting host entry factors on human nasal mucosa will be necessary for complete control of SARS-CoV-2. Our data reveal that ACE2 was more abundant in human nasal mucosa than lung tissue. Both ACE2 and TMPRSS2 transcriptions were significantly decreased in nasal epithelium in response to S. epidermidis and were relatively lower in human nasal mucus with large number of S. epidermidis. ACE2 transcription was also reduced in nasal epithelium in response to nasal symbiont S. aureus. This study propose that Staphylococcus species nasal commensals might potentially restrict SARS-CoV-2 entry to the nasal epithelium via down regulation of cellular receptors coupled with reduction of principal host protease.
Keywords: ACE2; COVID-19; SARS-CoV-2; Staphylococcus aureus; Staphylococcus epidermidis; TMPRSS2.