tetano
Editor, Senior Moderator
iScience
. 2020 Jul 25;23(8):101406.
doi: 10.1016/j.isci.2020.101406. Online ahead of print.
Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges
Tugba Kilic[SUP] 1 [/SUP], Ralph Weissleder[SUP] 2 [/SUP], Hakho Lee[SUP] 3 [/SUP]
Affiliations
Abstract
Rapid spread of coronavirus disease 2019 (COVID-19) is ravaging the globe. Since its first report in December 2019, COVID-19 cases have exploded to over 14 million as of July 2020, claiming more than 600,000 lives. Implementing fast and widespread diagnostic tests is paramount to contain COVID-19, given the current lack of an effective therapeutic or vaccine. This review focuses on a broad description of currently available diagnostic tests to detect either the virus (SARS-CoV-2) or virus-induced immune responses. We specifically explain the working mechanisms of these tests and compare their analytical performance. These analyses will assist in selecting most effective tests for a given application, for example, epidemiology or global pandemic research, population screening, hospital-based testing, home-based and point-of-care testing, and therapeutic trials. Finally, we lay out the shortcomings of certain tests and future needs.
Keywords: Analytical Chemistry; Diagnostic Equipment; Infection Control in Health Technology; Virology.
. 2020 Jul 25;23(8):101406.
doi: 10.1016/j.isci.2020.101406. Online ahead of print.
Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges
Tugba Kilic[SUP] 1 [/SUP], Ralph Weissleder[SUP] 2 [/SUP], Hakho Lee[SUP] 3 [/SUP]
Affiliations
- PMID: 32771976
- DOI: 10.1016/j.isci.2020.101406
Abstract
Rapid spread of coronavirus disease 2019 (COVID-19) is ravaging the globe. Since its first report in December 2019, COVID-19 cases have exploded to over 14 million as of July 2020, claiming more than 600,000 lives. Implementing fast and widespread diagnostic tests is paramount to contain COVID-19, given the current lack of an effective therapeutic or vaccine. This review focuses on a broad description of currently available diagnostic tests to detect either the virus (SARS-CoV-2) or virus-induced immune responses. We specifically explain the working mechanisms of these tests and compare their analytical performance. These analyses will assist in selecting most effective tests for a given application, for example, epidemiology or global pandemic research, population screening, hospital-based testing, home-based and point-of-care testing, and therapeutic trials. Finally, we lay out the shortcomings of certain tests and future needs.
Keywords: Analytical Chemistry; Diagnostic Equipment; Infection Control in Health Technology; Virology.