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iScience . Intensity and drivers of subtypes interference between seasonal influenza viruses in mainland China: A modeling study

tetano

Editor, Senior Moderator
iScience


. 2024 Feb 23;27(3):109323.
doi: 10.1016/j.isci.2024.109323. eCollection 2024 Mar 15. Intensity and drivers of subtypes interference between seasonal influenza viruses in mainland China: A modeling study

Can Chen[SUP] 1 [/SUP], Mengya Yang[SUP] 1 [/SUP], Yu Wang[SUP] 2 [/SUP], Daixi Jiang[SUP] 1 [/SUP], Yuxia Du[SUP] 1 [/SUP], Kexin Cao[SUP] 1 [/SUP], Xiaobao Zhang[SUP] 1 [/SUP], Xiaoyue Wu[SUP] 1 [/SUP], Mengsha Chen[SUP] 1 [/SUP], Yue You[SUP] 1 [/SUP], Wenkai Zhou[SUP] 1 [/SUP], Jiaxing Qi[SUP] 1 [/SUP], Rui Yan[SUP] 1 [/SUP], Changtai Zhu[SUP] 3 [/SUP], Shigui Yang[SUP] 1 [/SUP]



Affiliations
Abstract

Subtype interference has a significant impact on the epidemiological patterns of seasonal influenza viruses (SIVs). We used attributable risk percent [the absolute value of the ratio of the effective reproduction number (Rₑ) of different subtypes minus one] to quantify interference intensity between A/H1N1 and A/H3N2, as well as B/Victoria and B/Yamagata. The interference intensity between A/H1N1 and A/H3N2 was higher in southern China 0.26 (IQR: 0.11-0.46) than in northern China 0.17 (IQR: 0.07-0.24). Similarly, interference intensity between B/Victoria and B/Yamagata was also higher in southern China 0.14 (IQR: 0.07-0.24) than in norther China 0.10 (IQR: 0.04-0.18). High relative humidity significantly increased subtype interference, with the highest relative risk reaching 20.59 (95% CI: 6.12-69.33) in southern China. Southern China exhibited higher levels of subtype interference, particularly between A/H1N1 and A/H3N2. Higher relative humidity has a more pronounced promoting effect on subtype interference.

Keywords: Biological sciences; Immunology; Public health.

 
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