tetano
Editor, Senior Moderator
iScience
. 2021 Mar 5;102264.
doi: 10.1016/j.isci.2021.102264. Online ahead of print.
A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection
Jane E Sinclair[SUP] 1 [/SUP], Yanshan Zhu[SUP] 1 [/SUP], Gang Xu[SUP] 2 [/SUP], Wei Ma[SUP] 3 4 [/SUP], Haiyan Shi[SUP] 5 [/SUP], Kun-Long Ma[SUP] 6 [/SUP], Chun-Feng Cao[SUP] 6 [/SUP], Ling-Xi Kong[SUP] 6 [/SUP], Ke-Qiang Wan[SUP] 6 [/SUP], Juan Liao[SUP] 6 [/SUP], Hai-Qiang Wang[SUP] 7 [/SUP], Matt Arentz[SUP] 8 [/SUP], Meredith A Redd[SUP] 9 [/SUP], Linda A Gallo[SUP] 10 [/SUP], Kirsty R Short[SUP] 1 11 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyse the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease (CVD), hypertension or diabetes mellitus (DM)) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by ?10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR) 1.67[1.48,1.88]), CVD (OR 3.37[2.57,4.43]), hypertension (OR 2.68[2.11,3.41]), DM (OR 1.60[1.31,1.95]) and male sex (OR 1.31[1.21,1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management.
. 2021 Mar 5;102264.
doi: 10.1016/j.isci.2021.102264. Online ahead of print.
A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection
Jane E Sinclair[SUP] 1 [/SUP], Yanshan Zhu[SUP] 1 [/SUP], Gang Xu[SUP] 2 [/SUP], Wei Ma[SUP] 3 4 [/SUP], Haiyan Shi[SUP] 5 [/SUP], Kun-Long Ma[SUP] 6 [/SUP], Chun-Feng Cao[SUP] 6 [/SUP], Ling-Xi Kong[SUP] 6 [/SUP], Ke-Qiang Wan[SUP] 6 [/SUP], Juan Liao[SUP] 6 [/SUP], Hai-Qiang Wang[SUP] 7 [/SUP], Matt Arentz[SUP] 8 [/SUP], Meredith A Redd[SUP] 9 [/SUP], Linda A Gallo[SUP] 10 [/SUP], Kirsty R Short[SUP] 1 11 [/SUP]
Affiliations
- PMID: 33688629
- PMCID: PMC7934658
- DOI: 10.1016/j.isci.2021.102264
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyse the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease (CVD), hypertension or diabetes mellitus (DM)) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by ?10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR) 1.67[1.48,1.88]), CVD (OR 3.37[2.57,4.43]), hypertension (OR 2.68[2.11,3.41]), DM (OR 1.60[1.31,1.95]) and male sex (OR 1.31[1.21,1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management.