tetano
Editor, Senior Moderator
J Intensive Care Med. 2017 Jan 1:885066617701117. doi: 10.1177/0885066617701117. [Epub ahead of print]
[h=1]Is Therapeutic Hypothermia for Acute Respiratory Distress Syndrome the Future?[/h] Hayek AJ[SUP]1[/SUP], White HD[SUP]1[/SUP], Ghamande S[SUP]1[/SUP], Spradley C[SUP]1[/SUP], Arroliga AC[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]INTRODUCTION:[/h] Severe acute respiratory distress syndrome (ARDS) has a high mortality, and there is limited knowledge about management of severe ARDS refractory to standard therapy. Early evidence suggests that therapeutic hypothermia (TH) could be a viable treatment for acute respiratory failure. We present 2 cases where TH was successfully used to manage refractory ARDS on extracorporeal membrane oxygenation (ECMO) and a review of the literature around TH and acute respiratory failure.
[h=4]RESULTS:[/h] We present 2 cases of ARDS secondary to H1N1 influenza and human metapneumovirus. Both patients were treated with the current evidence-based therapy for ARDS. Venovenous ECMO was used in both patients for refractory hypoxemia. Therapeutic hypothermia was applied for 24 hours with improved oxygenation. We did a review of the literature summarizing 38 patients in 10 publications where TH was successfully utilized in the treatment of acute respiratory failure.
[h=4]CONCLUSION:[/h] Therapeutic hypothermia may be a viable salvage therapy for ARDS refractory to the current evidence-based therapy but needs further evaluation.
[h=4]KEYWORDS:[/h] acute respiratory distress syndrome; extracorporeal membrane oxygenation; refractory hypoxemia; therapeutic hypothermia
PMID: 28343415 DOI: 10.1177/0885066617701117
[h=1]Is Therapeutic Hypothermia for Acute Respiratory Distress Syndrome the Future?[/h] Hayek AJ[SUP]1[/SUP], White HD[SUP]1[/SUP], Ghamande S[SUP]1[/SUP], Spradley C[SUP]1[/SUP], Arroliga AC[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]INTRODUCTION:[/h] Severe acute respiratory distress syndrome (ARDS) has a high mortality, and there is limited knowledge about management of severe ARDS refractory to standard therapy. Early evidence suggests that therapeutic hypothermia (TH) could be a viable treatment for acute respiratory failure. We present 2 cases where TH was successfully used to manage refractory ARDS on extracorporeal membrane oxygenation (ECMO) and a review of the literature around TH and acute respiratory failure.
[h=4]RESULTS:[/h] We present 2 cases of ARDS secondary to H1N1 influenza and human metapneumovirus. Both patients were treated with the current evidence-based therapy for ARDS. Venovenous ECMO was used in both patients for refractory hypoxemia. Therapeutic hypothermia was applied for 24 hours with improved oxygenation. We did a review of the literature summarizing 38 patients in 10 publications where TH was successfully utilized in the treatment of acute respiratory failure.
[h=4]CONCLUSION:[/h] Therapeutic hypothermia may be a viable salvage therapy for ARDS refractory to the current evidence-based therapy but needs further evaluation.
[h=4]KEYWORDS:[/h] acute respiratory distress syndrome; extracorporeal membrane oxygenation; refractory hypoxemia; therapeutic hypothermia
PMID: 28343415 DOI: 10.1177/0885066617701117