tetano
Editor, Senior Moderator
Vaccines (Basel). 2020 Mar 27;8(2). pii: E150. doi: 10.3390/vaccines8020150.
Is an Increased Risk of Developing Guillain-Barr? Syndrome Associated with Seasonal Influenza Vaccination? A Systematic Review and Meta-Analysis.
Petr?š M[SUP]1[/SUP], Lesn? IK[SUP]2[/SUP], D?ňov? J[SUP]1[/SUP], Čelko AM[SUP]1[/SUP].
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Abstract
While the weight of epidemiological evidence does not support a causal link with influenza vaccination evaluated over the last 30 years, Guillain-Barr? syndrome (GBS) has been considered a vaccine-associated adverse event of interest since 1976. To investigate the existence of GBS risk after vaccination against seasonal influenza, a systematic review and meta-analysis have been conducted based on 22 eligible epidemiological studies from 1981 to 2019 reporting 26 effect sizes (ESs) in different influenza seasons. The primary result of our meta-analysis pointed to no risk of vaccine-associated GBS, as documented by a pooled ES of 1.15 (95% CI: 0.97-1.35). Conversely, an obvious high risk of GBS was observed in patients with previous influenza-like illness (ILI), as demonstrated by a pooled ES of 9.6 (95% CI: 4.0-23.0) resulting from a supplementary analysis. While the meta-analysis did not confirm the putative risk of vaccine-associated GBS suggested by many epidemiological studies, vaccination against seasonal influenza reduced the risk of developing ILI-associated GBS by about 88%. However, to obtain strong evidence, more epidemiological studies are warranted to establish a possible coincidence between vaccination and ILI prior to GBS onset.
KEYWORDS:
Guillain–Barr? syndrome; influenza-like illness; vaccine against seasonal influenza; vaccine-associated autoimmune disease
PMID:32230964DOI:10.3390/vaccines8020150
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Is an Increased Risk of Developing Guillain-Barr? Syndrome Associated with Seasonal Influenza Vaccination? A Systematic Review and Meta-Analysis.
Petr?š M[SUP]1[/SUP], Lesn? IK[SUP]2[/SUP], D?ňov? J[SUP]1[/SUP], Čelko AM[SUP]1[/SUP].
Author information
Abstract
While the weight of epidemiological evidence does not support a causal link with influenza vaccination evaluated over the last 30 years, Guillain-Barr? syndrome (GBS) has been considered a vaccine-associated adverse event of interest since 1976. To investigate the existence of GBS risk after vaccination against seasonal influenza, a systematic review and meta-analysis have been conducted based on 22 eligible epidemiological studies from 1981 to 2019 reporting 26 effect sizes (ESs) in different influenza seasons. The primary result of our meta-analysis pointed to no risk of vaccine-associated GBS, as documented by a pooled ES of 1.15 (95% CI: 0.97-1.35). Conversely, an obvious high risk of GBS was observed in patients with previous influenza-like illness (ILI), as demonstrated by a pooled ES of 9.6 (95% CI: 4.0-23.0) resulting from a supplementary analysis. While the meta-analysis did not confirm the putative risk of vaccine-associated GBS suggested by many epidemiological studies, vaccination against seasonal influenza reduced the risk of developing ILI-associated GBS by about 88%. However, to obtain strong evidence, more epidemiological studies are warranted to establish a possible coincidence between vaccination and ILI prior to GBS onset.
KEYWORDS:
Guillain–Barr? syndrome; influenza-like illness; vaccine against seasonal influenza; vaccine-associated autoimmune disease
PMID:32230964DOI:10.3390/vaccines8020150
Free full text