tetano
Editor, Senior Moderator
Annu Rev Med. 2019 Oct 10. doi: 10.1146/annurev-med-120617-041310. [Epub ahead of print] [h=1]Is a Universal Influenza Virus Vaccine Possible?[/h]
Nachbagauer R[SUP]1[/SUP], Palese P[SUP]2[/SUP].
[h=3]Author information[/h] 1 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; email: raffael.nachbagauer@mssm.edu. 2 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; email: peter.palese@mssm.edu.
[h=3]Abstract[/h] Influenza viruses remain a severe burden to human health because of their contribution to overall morbidity and mortality. Current seasonal influenza virus vaccines do not provide sufficient protection to alleviate the annual impact of influenza and cannot confer protection against potentially pandemic influenza viruses. The lack of protection is due to rapid changes of the viral epitopes targeted by the vaccine and the often suboptimal immunogenicity of current immunization strategies. Major efforts to improve vaccination approaches are under way. The development of a universal influenza virus vaccine may be possible by combining the lessons learned from redirecting the immune response toward conserved viral epitopes, as well as the use of adjuvants and novel vaccination platforms. Expected final online publication date for the Annual Review of Medicine, Volume 71 is January 27, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 31600454 DOI: 10.1146/annurev-med-120617-041310
Nachbagauer R[SUP]1[/SUP], Palese P[SUP]2[/SUP].
[h=3]Author information[/h] 1 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; email: raffael.nachbagauer@mssm.edu. 2 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; email: peter.palese@mssm.edu.
[h=3]Abstract[/h] Influenza viruses remain a severe burden to human health because of their contribution to overall morbidity and mortality. Current seasonal influenza virus vaccines do not provide sufficient protection to alleviate the annual impact of influenza and cannot confer protection against potentially pandemic influenza viruses. The lack of protection is due to rapid changes of the viral epitopes targeted by the vaccine and the often suboptimal immunogenicity of current immunization strategies. Major efforts to improve vaccination approaches are under way. The development of a universal influenza virus vaccine may be possible by combining the lessons learned from redirecting the immune response toward conserved viral epitopes, as well as the use of adjuvants and novel vaccination platforms. Expected final online publication date for the Annual Review of Medicine, Volume 71 is January 27, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 31600454 DOI: 10.1146/annurev-med-120617-041310