tetano
Editor, Senior Moderator
Ir J Med Sci
. 2023 Feb 9.
doi: 10.1007/s11845-022-03266-6. Online ahead of print.
The risk of mortality and severe illness in patients infected with the omicron variant relative to delta variant of SARS-CoV-2: a systematic review and meta-analysis
Chia Siang Kow[SUP] 1 2 [/SUP], Dinesh Sangarran Ramachandram[SUP] 3 [/SUP], Syed Shahzad Hasan[SUP] 4 5 [/SUP]
Affiliations
Abstract
We summarized through systematic review and meta-analysis of observational studies the risk of mortality as well as severe illness of COVID-19 caused by omicron variant relative to delta variant of SARS-CoV-2. A total of twelve studies were included. Our results showed significantly reduced odds of mortality (pooled OR = 0.33; 95% CI: 0.16-0.67) and significantly reduced odds of severe illness (pooled OR = 0.24; 95% CI: 0.21-0.28) in patients infected with the omicron variant of SARS-CoV-2 relative to their counterparts infected with the delta variant. Findings of lower disease severity following infection with the omicron variant of SARS-CoV-2 than the delta variant are encouraging during the ongoing transition from the pandemic phase into the endemic phase of COVID-19.
Keywords: Coronavirus; Delta; Omicron; Variant.
. 2023 Feb 9.
doi: 10.1007/s11845-022-03266-6. Online ahead of print.
The risk of mortality and severe illness in patients infected with the omicron variant relative to delta variant of SARS-CoV-2: a systematic review and meta-analysis
Chia Siang Kow[SUP] 1 2 [/SUP], Dinesh Sangarran Ramachandram[SUP] 3 [/SUP], Syed Shahzad Hasan[SUP] 4 5 [/SUP]
Affiliations
- PMID: 36754948
- DOI: 10.1007/s11845-022-03266-6
Abstract
We summarized through systematic review and meta-analysis of observational studies the risk of mortality as well as severe illness of COVID-19 caused by omicron variant relative to delta variant of SARS-CoV-2. A total of twelve studies were included. Our results showed significantly reduced odds of mortality (pooled OR = 0.33; 95% CI: 0.16-0.67) and significantly reduced odds of severe illness (pooled OR = 0.24; 95% CI: 0.21-0.28) in patients infected with the omicron variant of SARS-CoV-2 relative to their counterparts infected with the delta variant. Findings of lower disease severity following infection with the omicron variant of SARS-CoV-2 than the delta variant are encouraging during the ongoing transition from the pandemic phase into the endemic phase of COVID-19.
Keywords: Coronavirus; Delta; Omicron; Variant.