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Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses

tetano

tetano

Editor, Senior Moderator
Virology. 2013 Apr 22. pii: S0042-6822(13)00180-3. doi: 10.1016/j.virol.2013.03.027. [Epub ahead of print]
Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses.
Tretyakova I, Pearce MB, Florese R, Tumpey TM, Pushko P.
Source

Medigen, Inc., 4539 Metropolitan Court, Frederick, MD, USA.
Abstract

Avian influenza H5, H7 and H9 viruses top the World Health Organization's (WHO) list of subtypes with the greatest pandemic potential. Here we describe a recombinant virus-like particle (VLP) that co-localizes hemagglutinin (HA) proteins derived from H5N1, H7N2, and H9N2 viruses as an experimental vaccine against these viruses. A baculovirus vector was configured to co-express the H5, H7, and H9 genes from A/Viet Nam/1203/2004 (H5N1), A/New York/107/2003 (H7N2) and A/Hong Kong/33982/2009 (H9N2) viruses, respectively, as well as neuraminidase (NA) and matrix (M1) genes from A/Puerto Rico/8/1934 (H1N1) virus. Co-expression of these genes in Sf9 cells resulted in production of triple-subtype VLPs containing HA molecules derived from the three influenza viruses. The triple-subtype VLPs exhibited hemagglutination and neuraminidase activities and morphologically resembled influenza virions. Intranasal vaccination of ferrets with the VLPs resulted in induction of serum antibody responses and efficient protection against experimental challenges with H5N1, H7N2, and H9N2 viruses.

Copyright ? 2013 Elsevier Inc. All rights reserved.

PMID:
23618102
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23618102
 
Re: Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses

There is a currently available poultry H7 & H9 vaccine that is made in Pakistan. It's viral components are H7N3 and H9N2.

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Re: Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses

That sounds like a promising vaccine for humans at some point. :applause:
 
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