tetano
Editor, Senior Moderator
Intest Res
. 2020 Nov 6.
doi: 10.5217/ir.2020.00087. Online ahead of print.
An overview of the gut side of the SARS-CoV-2 infection
Bruna Barbosa da Luz[SUP] 1 [/SUP], Natalia Mulinari Turin de Oliveira[SUP] 2 3 [/SUP], Isabella Wzorek Fran?a Dos Santos[SUP] 2 3 [/SUP], Luana Zampieron Paza[SUP] 2 3 [/SUP], Lara Luisa Valerio de Mello Braga[SUP] 2 3 [/SUP], Fernanda da Silva Platner[SUP] 2 3 [/SUP], Maria Fernanda de Paula Werner[SUP] 1 [/SUP], Elizabeth Soares Fernandes[SUP] 2 3 [/SUP], Daniele Maria-Ferreira[SUP] 2 3 [/SUP]
Affiliations
Abstract
In late 2019, an outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiated in Wuhan, Hubei province, China. The major clinical symptoms described for coronavirus disease (COVID-19) include respiratory distress and pneumonia in severe cases, and some patients may experience gastrointestinal impairments. In accordance, viral RNA or live infectious virus have been detected in feces of patients with COVID-19. Binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) is a vital pathway for the virus entry into human cells, including those of the respiratory mucosa, esophageal epithelium as well as the absorptive enterocytes from ileum and colon. The interaction between SARS-CoV-2 and ACE2 receptor may decrease the receptor expression and disrupt the function of B0AT1 transporter influencing the diarrhea observed in COVID-19 patients. In this context, a fecal-oral transmission route has been considered and points out a role for the digestive tract in disease transmission and severity. Here, in order to further understand the impact of COVID-19 in human physiology, the cellular and molecular mechanisms of SARS-CoV-2 infection and disease severity are discussed in the context of gastrointestinal disturbances.
Keywords: ACE2; COVID-19; Coronavirus; Gastroenterology; Gastrointestinal manifestations.
. 2020 Nov 6.
doi: 10.5217/ir.2020.00087. Online ahead of print.
An overview of the gut side of the SARS-CoV-2 infection
Bruna Barbosa da Luz[SUP] 1 [/SUP], Natalia Mulinari Turin de Oliveira[SUP] 2 3 [/SUP], Isabella Wzorek Fran?a Dos Santos[SUP] 2 3 [/SUP], Luana Zampieron Paza[SUP] 2 3 [/SUP], Lara Luisa Valerio de Mello Braga[SUP] 2 3 [/SUP], Fernanda da Silva Platner[SUP] 2 3 [/SUP], Maria Fernanda de Paula Werner[SUP] 1 [/SUP], Elizabeth Soares Fernandes[SUP] 2 3 [/SUP], Daniele Maria-Ferreira[SUP] 2 3 [/SUP]
Affiliations
- PMID: 33142370
- DOI: 10.5217/ir.2020.00087
Abstract
In late 2019, an outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiated in Wuhan, Hubei province, China. The major clinical symptoms described for coronavirus disease (COVID-19) include respiratory distress and pneumonia in severe cases, and some patients may experience gastrointestinal impairments. In accordance, viral RNA or live infectious virus have been detected in feces of patients with COVID-19. Binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) is a vital pathway for the virus entry into human cells, including those of the respiratory mucosa, esophageal epithelium as well as the absorptive enterocytes from ileum and colon. The interaction between SARS-CoV-2 and ACE2 receptor may decrease the receptor expression and disrupt the function of B0AT1 transporter influencing the diarrhea observed in COVID-19 patients. In this context, a fecal-oral transmission route has been considered and points out a role for the digestive tract in disease transmission and severity. Here, in order to further understand the impact of COVID-19 in human physiology, the cellular and molecular mechanisms of SARS-CoV-2 infection and disease severity are discussed in the context of gastrointestinal disturbances.
Keywords: ACE2; COVID-19; Coronavirus; Gastroenterology; Gastrointestinal manifestations.