Sally Furniss
Well-known member
Interspecific Hybridization Yields Strategy for South Pacific Filariasis Vector Elimination
Corey L. Brelsfoard,1 Yves S?chan,2 and Stephen L. Dobson1*
1Department of Entomology, University of Kentucky, Lexington, Kentucky, United States of America
2Institut Louis Malard?, Papeete, French Polynesia
Photini Sinnis, Academic Editor
New York University School of Medicine, United States of America
* E-mail: sdobson@uky.edu
Conceived and designed the experiments: SD CB. Performed the experiments: CB. Analyzed the data: SD CB. Contributed reagents/materials/analysis tools: YS. Wrote the paper: SD CB. Other: Provided mosquito strains: YS.
Received May 29, 2007; Accepted October 26, 2007.
Background
Lymphatic filariasis (LF) is a leading cause of disability in South Pacific regions, where >96% of the 1.7 million population are at risk of LF infection. As part of current global campaign, mass drug administration (MDA) has effectively reduced lymphatic filiariasis prevalence, but mosquito vector biology can complicate the MDA strategy. In some regions, there is evidence that the goal of LF elimination cannot be attained via MDA alone. Obligate vector mosquitoes provide additional targets for breaking the LF transmission cycle, but existing methods are ineffective for controlling the primary vector throughout much of the South Pacific, Aedes polynesiensis.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2217672
Corey L. Brelsfoard,1 Yves S?chan,2 and Stephen L. Dobson1*
1Department of Entomology, University of Kentucky, Lexington, Kentucky, United States of America
2Institut Louis Malard?, Papeete, French Polynesia
Photini Sinnis, Academic Editor
New York University School of Medicine, United States of America
* E-mail: sdobson@uky.edu
Conceived and designed the experiments: SD CB. Performed the experiments: CB. Analyzed the data: SD CB. Contributed reagents/materials/analysis tools: YS. Wrote the paper: SD CB. Other: Provided mosquito strains: YS.
Received May 29, 2007; Accepted October 26, 2007.
Background
Lymphatic filariasis (LF) is a leading cause of disability in South Pacific regions, where >96% of the 1.7 million population are at risk of LF infection. As part of current global campaign, mass drug administration (MDA) has effectively reduced lymphatic filiariasis prevalence, but mosquito vector biology can complicate the MDA strategy. In some regions, there is evidence that the goal of LF elimination cannot be attained via MDA alone. Obligate vector mosquitoes provide additional targets for breaking the LF transmission cycle, but existing methods are ineffective for controlling the primary vector throughout much of the South Pacific, Aedes polynesiensis.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2217672